Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Reacts with a PI-linked glycoprotein. This antibody has been shown to stimulate NK activity. Recognizes an epitope distinct to that bound by LS-C5424.
Suitable for use in Flow Cytometry, Immunohistochemistry, ELISA, Immunoprecipitation and Western Blot. Flow Cytometry: 1:5-1:10. Use 10 ul to label 1E6 cells in 100ul. Immunohistochemistry (Frozen & Paraffin): Antigen retrieval using heat treatment methods prior to staining of paraffin sections is required. Sodium citrate buffer, pH 6.0, is recommended for this procedure. Positive control: Tonsil.
PBS, pH 7.2, 0.09% sodium azide.
Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
CD59 is a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation.