Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone MEM-43] (IgG2a) to Human CD59
Human (tested or 100% immunogen sequence identity)
IgG2a Monoclonal [MEM-43]
Specificity and Use
CD59 antibody was raised against thymocytes and T lymphocytes.
Reacts with well defined epitope (W40, R-53) on CD59 (Protectin), an 18-20 kD glycosylphosphatidylinositol (GPI)-anchored glycoprotein expressed on all hematopoietic cells; it is widely present on cells in all tissues.
The reagent is designed for Flow Cytometry analysis of human blood cells using 10 ul reagent / 100 ul of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
PBS, 15 mM sodium azide, 0.2% high-grade protease free BSA as a stabilizing agent.
Store at 4°C. Product is photosensitive and should be protected from light.
CD59 is a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation.