Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
CD59 is a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation.
Western Blot analysis of CD59 expression in transfected 293T cell line by CD59 monoclonal antibody (M02), clone 3G6.Lane 1: CD59 transfected lysate (Predicted MW: 41.2 KDa).Lane 2: Non-transfected lysate.
CD59 monoclonal antibody (M02), clone 3G6. Western Blot analysis of CD59 expression in HeLa.
Enzyme-Linked Immunosorbent Assay
Detection limit for recombinant GST tagged CD59 is 1 ng/ml as a capture antibody.