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CD46
CD46 molecule, complement regulatory protein
Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.
| Gene Name: | CD46 molecule, complement regulatory protein |
| Synonyms: | CD46, AHUS2, CD46 antigen, MCP, Measles virus receptor, TLX, MIC10, TRA2.10, Membrane cofactor protein |
| Target Sequences: | NM_002389 NP_002380.3 P15529 |
Publications (1)
1
Vaccination with adenovirus serotypes 35, 26, and 48 elicits higher levels of innate cytokine responses than adenovirus serotype 5 in rhesus monkeys. Teigler JE, Iampietro MJ, Barouch DH. Journal of virology. 2012 86:9590-8. (IHC-P)
[Full Text Article]
[PubMed:22787208]
Related Antibodies: LS-C96281.
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CD46 Mouse anti-Human Monoclonal (MEM-258) Antibody
Human
Flo, IF, IHC, IHC-P, IP, WB
Unconjugated
0.05 mg/$460
CD46 Mouse anti-Human Monoclonal (RPE) (MEM-258) Antibody
Human
Flo
RPE Conjugated
100 Tests/$485
CD46 Mouse anti-Human Monoclonal (3F1) Antibody
Human
ELISA, Flo, ICC, IHC, IHC-P, WB
Unconjugated
100 µg/$485
CD46 Mouse anti-Human Monoclonal (13/42) Antibody
Human
IHC, IHC-Fr, IHC-P
Unconjugated
200 µg/$595
CD46 Rat anti-Mouse Monoclonal (MM10) Antibody
Mouse, Rat
Flo, IF, IHC, IHC-Fr, WB
Unconjugated
100 µg/$554
CD46 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
CD46 Mouse anti-Human Monoclonal (Concentrated) (M177) Antibody
Human
Flo, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated, Concentrated
50 µg/$565
CD46 Mouse anti-Human Monoclonal (Azide-free) (MEM-258) Antibody
Bovine, Human
Flo, IP, WB
Unconjugated, Azide-free
0.1 mg/$309
CD46 Mouse anti-Human Monoclonal (Azide-free) (169-1-EA.3) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated, Azide-free
50 µg/$460
CD46 Rabbit anti-Human Polyclonal (aa317-343) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
CD46 Mouse anti-Human Monoclonal (FITC) Antibody
Human
Flo, IHC, IHC-Fr, IHC-P, IP, WB
FITC Conjugated
100 µg/$873
CD46 Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µg/$575
CD46 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IP, WB
Unconjugated
100 µg/$331
CD46 Mouse anti-Human Monoclonal (APC) (MEM-258) Antibody
Bovine, Human
Flo, IP, WB
APC Conjugated
100 Tests/$365
CD46 Mouse anti-Human Monoclonal (FITC) Antibody
Human
Flo, WB
FITC Conjugated
120 Tests/$626
CD46 Mouse anti-Human Monoclonal (1A5A5) Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
100 µg/$459
CD46 Mouse anti-Human Monoclonal (5A8C11) Antibody
Human
ELISA, Flo, ICC, WB
Unconjugated
100 µg/$459
CD46 Rabbit anti-Human Polyclonal (aa317-343) Antibody
Human
ELISA, Flo, IF, IHC, WB
Unconjugated
200 µl/$734
CD46 Rabbit anti-Human Polyclonal (aa317-343) (Biotin) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
Biotin Conjugated
200 µl/$952
CD46 Rabbit anti-Human Polyclonal (aa317-343) (FITC) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
FITC Conjugated
200 µl/$952
CD46 Rabbit anti-Human Polyclonal (aa317-343) (PE) Antibody
Human
ELISA, ICC, IF, IHC, WB
PE Conjugated
200 µl/$952
CD46 Rabbit anti-Human Polyclonal (aa317-343) (APC) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
APC Conjugated
200 µl/$952
CD46 Rabbit anti-Human Polyclonal (aa317-343) (Azide-free) (HRP) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
CD46 Mouse anti-Human Monoclonal (AT2G9) Antibody
Human
ELISA, Flo, ICC, IHC, WB
Unconjugated
50 µl/$303; 100 µl/$365
CD46 Mouse anti-Human Monoclonal (FITC) Antibody
Human
Flo
FITC Conjugated
25 Tests/$263; 100 Tests/$323
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