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Anti-CD46 Antibody (clone MEM-258, Azide-free) LS-C45713

Catalog Size Price
LS-C45713-100 100 µg (1 mg/ml) Unavailable

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100% Guaranteed
Mouse Monoclonal [clone MEM-258] (IgG1) to Human CD46
Human, Bovine
Western blot, Immunoprecipitation, Flow Cytometry
Unconjugated, Azide-free

Details

Human CD46
Mouse
Human, Bovine (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [MEM-258]
Unconjugated
Protein A purified
Azide-free

Applications

  • Western blot
  • Immunoprecipitation
  • Flow Cytometry

  • IHC - Paraffin

Specificity and Use

CD46 antibody was raised against hPB-ALL human T cell line.
Recognizes an epitope on SCR4 (the membrane-proximal SCR) domain of CD46 (Membrane cofactor protein). CD46 is 56-66 kD dimeric transmembrane protein expressed on T and B lymphocytes, platelets, monocytes, granulocytes, endothelial cells, epithelial cells and fibroblast; it is negative on erythrocytes.
Flow Cytometry: Recommended dilution - 1 ug/ml. Western Blotting: Application note - Non-reducing conditions. The applications listed have been tested for the unmodified form of this product. Other forms have not been tested.

Packaging

Azide free PBS, preserved by filter sterilization, approx., pH 7.4.
Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
For research use only.

About CD46

P15529 NM_002389 NP_002380.3

CD46 Antibody, AHUS2 Antibody, CD46 antigen Antibody, MCP Antibody, Measles virus receptor Antibody, TLX Antibody, MIC10 Antibody, TRA2.10 Antibody, Membrane cofactor protein Antibody

Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells.

Requested From: 
Date Requested: 6/24/2017

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