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Anti-CD45 / LCA Antibody (clone UM16-6, FITC) LS-C44824

Ordering

Wt. Vol. Conc. Price
100 µg - 0.1 mg/ml $445
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular CD45 / LCA Antibodies

Anti-CD45 / LCA Antibody (PE) LS-C127700
Mouse Monoclonal (IgG1) to Sheep CD45 / LCA
Sheep, Bovine, Goat
Flow Cytometry
PE Conjugated
Anti-CD45 / LCA Antibody (Internal) IHC-plus™ LS-A9435
Rabbit Polyclonal to Human CD45 / LCA
Human
IHC - Paraffin
Unconjugated
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed
Mouse Monoclonal [clone UM16-6] (IgG2a) to Chicken CD45 / LCA
Chicken
Flow Cytometry
FITC Conjugated

Details

Chicken CD45 / LCA
Mouse
Chicken (tested or 100% immunogen sequence identity)
IgG2a Monoclonal [UM16-6]
Fluorescein
Protein G purified
Unmodified

Applications

Flow Cytometry (1:1 - 1:10)

Specificity and Use

CD45 / LCA antibody was raised against cOS cells transfected with CD45 gene.
Recognizes chicken CD45 (leucocyte common antigen), a heavily-glycosylated transmembrane protein tyrosine phosphatase (PTPase) expressed by all nucleated cells of hematopoietic origin. Variation in the expression of a particular CD45 isoform, is regulated during the hematopoietic development of the different cell lineages. CD45 is essential for antigen-induced signal transduction through the antigen receptor and as with other PTPase family members, acts in balance with protein tyrosine kinases, causing the dephosphorylation of negative regulatory tyrosine sites. Studies have indicated that dephosphorylation by CD45, is required for the activation of the src-family kinases p56lck and p59fyn. Investigations into the properties of CD45 in chicken models are limited, but there is evidence of the existence of an additional cysteine residue near the transmembrane region. The overall domain structure between mammalian and chicken CD45 appears to be conserved, but the sequence homology between the extracellular regions is very low.
Flow Cytometry: Use 10 ul of the suggested working dilution to label 10^6 cells in 100 ul. The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.

Packaging

0.09% sodium azide, 1% BSA.
Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
For research use only.

About CD45 / LCA

P08575 NM_002838 NP_002829.3

PTPRC Antibody, B220 Antibody, CD45R Antibody, CD45 Antibody, gp180 Antibody, Leukocyte common antigen Antibody, L-CA Antibody, Leucocyte common antigen Antibody, LY5 Antibody, T200 Antibody, T200 glycoprotein Antibody, T200 leukocyte common antigen Antibody, CD45 antigen Antibody, LCA Antibody

CD45 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP.

Requested From: United States
Date Requested: 12/7/2016

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