Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone BRA-55] (IgG1) to Human CD45 / LCA
IHC - Paraffin, IHC - Frozen
Human CD45 / LCA
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [BRA-55]
IHC - Paraffin
IHC - Frozen
Specificity and Use
CD45 / LCA antibody was raised against isolated from REH6 cell line.
Clone LCA (CD45) is a useful marker to differentiate between lymphomas and carcinomas. Since this monoclonal gives a pronounced staining on formalin fixed paraffin embedded cells it is very useful in routine pathology. Reactive with 170-220 kD cell surface glycoprotein(s).
Ascites, sodium azide
Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
CD45 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP.