Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone 2H12] (IgG2b) to Human CD45 / LCA
Flow Cytometry, ELISA
Human CD45 / LCA
Human (tested or 100% immunogen sequence identity)
IgG2b Monoclonal [2H12]
Protein G purified
IHC - Paraffin
Specificity and Use
CD45 / LCA antibody was raised against recombinant human CD45 (1029-1249aa) purified from E. coli.
The antibody has been tested by ELISA and FACS analysis to assure specificity and reactivity. Since application varies, however, each investigation should titrate the reagent to obtain optimal results.
PBS, pH 7.4, 0.1% sodium azide
Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles.
CD45 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP.