Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone CVS18] (IgG1) to Horse CD44
IHC - Frozen, Flow Cytometry
Horse (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [CVS18]
Tissue culture supernatant
IHC - Frozen (1:1)
Flow Cytometry (1:1)
Specificity and Use
CD44 antibody was raised against equine leucocytes.
Recognizes equine CD44, a plasma membrane glycoprotein broadly expressed on the cell surface of leucocytes. CD44 is the primary receptor for hyaluronate and functions in cell adhesion. Equine CD44 is widely expressed andmay be used as a pan equine leucocyte marker.
Flow Cytometry: Use 10 ul of the suggested working dilution to label 10^6 cells in 100 ul.
Tissue Culture Supernatant containing 0.4M Tris/HCl pH 7.4 and 10% foetal calf serum and 0.09% sodium azide
Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis.