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CD4

CD4 molecule

CD4 is a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene.

Gene Name:	CD4 molecule
Synonyms:	CD4, CD4 antigen, CD4 receptor, CD4mut, CD4 antigen (p55), CD4 molecule
Target Sequences:	NM_000616 NP_000607.1 P01730

Publications (10)

Induction of Th1/Th17 immune response by Mycobacterium tuberculosis: role of dectin-1, Mannose Receptor, and DC-SIGN. Zenaro E, Donini M, Dusi S. Journal of leukocyte biology. 2009 86:1393-401. [PubMed:19773555]

Human T cells express CD25 and Foxp3 upon activation and exhibit effector/memory phenotypes without any regulatory/suppressor function. Kmieciak M, Gowda M, Graham L, Godder K, Bear HD, Marincola FM, Manjili MH. Journal of translational medicine. 2009 7:89. [PubMed:19849846] [PMC:PMC2770477] Related Antibodies: LS-C41126.

Loss of naive T cells and repertoire constriction predict poor response to vaccination in old primates. Cicin-Sain L, Smyk-Pearson S, Smyk-Paerson S, Currier N, Byrd L, Koudelka C, Robinson T, Swarbrick G, Tackitt S, Legasse A, Fischer M, Nikolich-Zugich D, Park B, Hobbs T, Doane CJ, Mori M, Axthelm MK, Axthelm MT, Lewinsohn DA, Nikolich-Zugich J. Journal of immunology (Baltimore, Md. : 1950). 2010 184:6739-45. [PubMed:20483749] [PMC:PMC3504654] Related Antibodies: LS-C41126.

Survival of skin graft between transgenic cloned dogs and non-transgenic cloned dogs. Kim GA, Oh HJ, Kim MJ, Jo YK, Choi J, Park JE, Park EJ, Lim SH, Yoon BI, Kang SK, Jang G, Lee BC. PloS one. 2014 9:e108330. (IP; Dog) [Full Text Article] [PubMed:25372489] [PMC:PMC4220905] Related Antibodies: LS-C122857.

Acute BVDV-2 infection in beef calves delays humoral responses to a non-infectious antigen challenge. UCVM Class of, McCorkell R, Horsman SR, Wynne-Edwards K, Muench G, van Drunen Littel-van den Hurk S, Waeckerlin R, Eschbaumer M, Dardari R, Chaiyakul M, Gajda P, Czub M, van der Meer F. The Canadian veterinary journal = La revue veterinaire canadienne. 2015 56:1075-83. (IP; Bovine) [PubMed:26483584] [PMC:PMC4572827]

Conformational Engineering of HIV-1 Env Based on Mutational Tolerance in the CD4 and PG16 Bound States. Jeremiah D Heredia, Jihye Park, Hannah Choi, Kevin S Gill, Erik Procko. Journal of virology. 2019 June;93: [Full Text Article] [PubMed:30894475] [PMC:PMC6532070] Related Antibodies: LS-C134227.

Crucial role of OX40/OX40L signaling in a murine model of asthma. Wei Lei, Daxiong Zeng, Gaoqin Liu, Yehan Zhu, Jiajia Wang, Hongya Wu, Junhong Jiang, Jianan Huang. Molecular medicine reports. 2018 Mar;17:4213-4220. [Full Text Article] [PubMed:29344664] [PMC:PMC5802192] Related Antibodies: LS-C62734.

Correlation between innate and adaptive immunity response in TB children post BCG vaccination. Is it effective or not?: Cross-sectional study. Rahmini Shabariah, Farsida, Mochammad Hatta, Ilhamjaya Patellongi, Irfan Idris, Arif Santoso, Andi Asadul Islam, Rosdiana Natzir, Bob Wahyudin, Warsinggih, Sanjoyo. Annals of medicine and surgery (2012). 2022 May;77:103586. [Full Text Article] [PubMed:35638072] [PMC:PMC9142374]

Comparison TLR2 and TLR4 serum levels in children with pulmonary and extrapulmonary tuberculosis with and without a Bacillus Calmette-Guérin (BCG) scar. Rahmini Shabariah, Mochammad Hatta, Irfan Idris, Arif Santoso, Ilhamjaya Patellongi, Tria Astika Endah Permatasari, Farsida, Andi Asadul Islam, Rosdiana Natzir, Bob Wahyudin, Warsinggih, Emilda. Journal of clinical tuberculosis and other mycobacterial diseases. 2021 December;25:100272. [Full Text Article] [PubMed:34504953] [PMC:PMC8416952]

EFFECT OF LIPOSOMAL CLODRONATE-DEPENDENT DEPLETION OF PROFESSIONAL ANTIGEN PRESENTING CELLS ON NUMBERS AND PHENOTYPE OF CANINE CD4+CD25+FOXP3+ REGULATORY T CELLS. Weaver KF, Stokes JV, Gunnoe SA, Follows JS, Shafer L, Ammari MG, Archer TM, Thomason JM, Mackin AJ, Pinchuk LM. Journal of veterinary medicine and research. 2014 1: (Flo; Canine) [PubMed:25950023] [PMC:PMC4418640] Related Antibodies: LS-C127352.

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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