Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone PS1] (IgG2a) to Human CD3E
Human (tested or 100% immunogen sequence identity)
IgG2a Monoclonal [PS1]
Tissue culture supernatant
Specificity and Use
CD3E antibody was raised against epsilon Chain of CD3.
Reacts specifically with the epsilon chain of the CD3 complex. This antibody is a pan T cell marker. On the lymphocyte surface, this antibody binds to 22/26/30 kD molecule, which is associated with T cell antigen receptor complex. This antibody reacts with T cell chronic lymphocytic leukemias as well as with acute lymphoblastic leukemias of T cell origin.
CD3E is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development.