Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Hamster Monoclonal [clone 145-2C11] (IgG) to Mouse CD3E
Mouse (tested or 100% immunogen sequence identity)
IgG Monoclonal [145-2C11]
Protein G purified
Flow Cytometry (1 µg/10E6 cells)
Specificity and Use
CD3E antibody was raised against h-2Kb sp.
Anti-mouse CD3 epsilon monoclonal antibody is specific for a 25 kD protein component (epsilon-T3) of the antigen specific T cell receptor on all mouse strains tested. The epsilon-T3 protein has been shown to be non-covalently associated on the cell surfa.
CD3E is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development.