Human CD34

Mouse

Human, Cynomolgus monkey, Rhesus monkey (tested or 100% immunogen sequence identity)

Rat, Bovine, Dog, Sheep

IgG1,k Monoclonal

QBEnd/10

Unconjugated

Protein G purified

Ready-to-Use. Also available Unmodified or Azide-free, BSA-free.

A detergent solubilized vesicular suspension prepared from human term placenta.

N-Terminus

Human CD34

• IHC
• IHC - Paraffin (1:1)
• Immunofluorescence
• Western blot
• Immunoprecipitation
• Flow Cytometry

The applications listed have been tested for the unmodified form of this product. Other forms have not been tested. This antibody recognizes a single chain, transmembrane, heavily glycosylated protein of 90-120kDa, which is identified as CD34. On the basis of differential sensitivity to degradation by specific enzymes, epitopes of monoclonal antibodies to CD34 are classified into three main categories, class I, class II and class III. This is a class II antibody whose epitope is resistant to neuraminidase but sensitive to glycoprotease and chymopapain. CD34 expression is a hallmark for identifying pluripotent hematopoietic stem or progenitor cells. Its expression is gradually lost as lineage committed progenitors differentiate. CD34 is a marker of choice for staining blasts in acute myeloid leukemia. In addition, it is expressed by soft tissue tumors, such as solitary fibrous tumor and gastrointestinal stromal tumor. Its expression is also found in vascular endothelium. Additionally, it appears that proliferating endothelial cells express this molecule more than the non-proliferating endothelial cells. CD34 antibody labels > 85% of angiosarcoma and Kaposi's sarcoma, but with a lower specificity.

1X PBS, 0.1 mg/ml BSA, 0.05% sodium azide

Store at 2°C to 8°C.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P28906 NCBI: NM_001773 NP_001764.1