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CD27L / CD70
CD70 molecule
CD27L / CD70 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.
| Gene Name: | CD70 molecule |
| Family/Subfamily: | TNF , not assigned-TNF |
| Synonyms: | CD70, CD27LG, Ki-24 antigen, Surface antigen CD70, CD27 ligand, CD27-L, CD70 antigen, CD70 molecule, TNFSF7 |
| Target Sequences: | NM_001252 NP_001243.1 P32970 |
Publications (3)
1
Mass Cytometry Analysis Reveals that Specific Intratumoral CD4+<sup> T Cell Subsets Correlate with Patient Survival in Follicular Lymphoma. Yang ZZ, Kim HJ, Villasboas JC, Price-Troska T, Jalali S, Wu H, Luchtel RA, Polley MC, Novak AJ, Ansell SM. Cell reports. 2019 February;26:2178-2193. [Full Text Article]
[PubMed:30784598]
[PMC:PMC6402596]
Related Antibodies: LS-A8809.
2
CD70 defines a subset of proinflammatory and CNS-pathogenic TH1/TH17 lymphocytes and is overexpressed in multiple sclerosis. Tessa Dhaeze, Laurence Tremblay, Catherine Lachance, Evelyn Peelen, Stephanie Zandee, Camille Grasmuck, Lyne Bourbonnière, Sandra Larouche, Xavier Ayrignac, Rose-Marie Rébillard, Josée Poirier, Boaz Lahav, Pierre Duquette, Marc Girard, Robert Moumdjian, Alain Bouthillier, Catherine Larochelle, Alexandre Prat. Cellular & molecular immunology. 2019 Jul;16:652-665. [Full Text Article]
[PubMed:30635649]
[PMC:PMC6804668]
3
CD70-specific CAR T cells have potent activity against acute myeloid leukemia without HSC toxicity. Tim Sauer, Kathan Parikh, Sandhya Sharma, Bilal Omer, David Sedloev, Qian Chen, Linus Angenendt, Christoph Schliemann, Michael Schmitt, Carsten Müller-Tidow, Stephen Gottschalk, Cliona M Rooney. Blood. 2021 July;138:318-330. [Full Text Article]
[PubMed:34323938]
[PMC:PMC8323977]
Related Antibodies: LS-A8809.
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CD27L / CD70 Rabbit anti-Human Polyclonal (Internal) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$440
Fast Shipping
CD27L / CD70 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$440
CD27L / CD70 Mouse anti-Human Monoclonal (BU69) Antibody
Human
ELISA, Flo, Func, ICC, IHC, IHC-Fr
Unconjugated
100 µg/$411
CD27L / CD70 Mouse anti-Human Monoclonal (Biotin) (BU69) Antibody
Human
ELISA, Flo, Func, ICC, IHC, IHC-Fr
Biotin Conjugated
100 µg/$446
CD27L / CD70 Mouse anti-Human Monoclonal (FITC) (BU69) Antibody
Human
ELISA, Flo, Func, ICC, IHC, IHC-Fr
FITC Conjugated
120 Tests/$446
CD27L / CD70 Mouse anti-Human Monoclonal (RPE) (BU69) Antibody
Human
ELISA, Flo, Func, ICC, IHC, IHC-Fr
RPE Conjugated
120 Tests/$511
CD27L / CD70 Mouse anti-Human Monoclonal (Azide-free) (BU69) Antibody
Human
ELISA, Flo, Func, ICC, IHC, IHC-Fr
Unconjugated, Azide-free
100 µg/$411
CD27L / CD70 Mouse anti-Human Monoclonal (Bu69) Antibody
Human
Flo, IHC, IHC-Fr
Unconjugated
0.2 mg/$471
Sandwich
96-Well Microplate
Human
0.3 - 70 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$672
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$798
CD27L / CD70 Rabbit anti-Human Polyclonal (aa52-101) Antibody
Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
CD27L / CD70 Rabbit anti-Human Polyclonal (aa72-101) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
CD27L / CD70 Rabbit anti-Human Polyclonal (aa31-80) Antibody
Human
WB
Unconjugated
100 µl/$424
CD27L / CD70 Rabbit anti-Human Polyclonal (aa31-80) (Biotin) Antibody
Rabbit, Guinea pig, Bovine, Human, Chimpanzee, Gibbon
WB
Biotin Conjugated
100 µl/$469
CD27L / CD70 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC-P
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CD27L / CD70 Mouse anti-Human Monoclonal (PE) (Ki-24) Antibody
Human
Flo
PE Conjugated
100 Tests/$365
CD27L / CD70 Mouse anti-Human Monoclonal (TNFS7/1026) Antibody
Human
ELISA, Flo, Func, IF, IHC, IHC-Fr, IP
Unconjugated
20 µg/$371; 100 µg/$574
CD27L / CD70 Mouse anti-Human Monoclonal (Azide-free, BSA-free) (TNFS7/1026) Antibody
Human
ELISA, Flo, Func, IF, IHC, IHC-Fr, IP
Unconjugated, Azide-free, BSA-free
100 µg/$574
CD27L / CD70 Mouse anti-Human Monoclonal (PE) (BU69) Antibody
Human
Flo, ICC, IHC, IHC-Fr, IP
PE Conjugated
50 µg/$359
CD27L / CD70 Rabbit anti-Human Polyclonal (aa72-101) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
CD27L / CD70 Rabbit anti-Human Polyclonal (aa72-101) (Biotin) Antibody
Human
ELISA, IHC, IHC-P, WB
Biotin Conjugated
200 µl/$952
CD27L / CD70 Rabbit anti-Human Polyclonal (aa72-101) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, IHC-P, WB
HRP Conjugated, Azide-free
200 µl/$952
CD27L / CD70 Rabbit anti-Human Polyclonal (aa72-101) (PE) Antibody
Human
ELISA, IHC, IHC-P, WB
PE Conjugated
200 µl/$952
CD27L / CD70 Mouse anti-Human Monoclonal (BU69) Antibody
Human
ELISA, Flo, Func, IF, IHC, IHC-Fr, IP
Unconjugated
20 µg/$371; 100 µg/$574
CD27L / CD70 Mouse anti-Human Monoclonal (Azide-free, BSA-free) (BU69) Antibody
Human
ELISA, Flo, Func, IF, IHC, IHC-Fr, IP
Unconjugated, Azide-free, BSA-free
100 µg/$574
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