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Anti-CD276 / B7-H3 Antibody (aa1-242, clone MJ8, RPE) LS-C187524


Wt. Vol. Conc. Price
- 100 tst - Unavailable

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100% Guaranteed 100% Guaranteed
Rat Monoclonal [clone MJ8] (IgG2b) to Mouse CD276 / B7-H3
Flow Cytometry
RPE Conjugated


Mouse CD276 / B7-H3
Mouse (tested or 100% immunogen sequence identity)
IgG2b Monoclonal [MJ8]
R. Phycoerythrin
Protein G purified


Flow Cytometry

Specificity and Use

CD276 / B7-H3 antibody was raised against mouse IgG2a Fc-CD276 (aa 1-242).
Recognizes mouse CD276, otherwise known as B7-H3, a ubiquitously expressed transmembrane glycoprotein and member of the B7 family of co-stimulatory molecules, which acts as both a positive and negative regulator of T-cell-mediated immune responses. CD276 is highly expressed in bone during embryogenesis, and can be induced on dendritic cells and monocytes by inflammatory cytokines. CD276 has been implicated in the development of acute and chronic transplant rejection, and is reported to have therapeutic potential as a regulator of cell-mediated immune responses to cancer, particularly in conjunction with anti-angiogenic therapy. In mice, CD276 has been linked with the development of pathogenic Th2 cells during the induction phase of allergic asthma, see for details.
The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.


PBS, 0.09% sodium azide, 1% BSA, 5% sucrose
100 tst Distilled water
Store at +4°C. Do not freeze. Protect from light.
For research use only.

About CD276 / B7-H3

Q5ZPR3 NM_025240 NP_079516.1

CD276 Antibody, 4Ig-B7-H3 Antibody, B7 homolog 3 Antibody, B7-H3 Antibody, CD276 antigen Antibody, CD276 molecule Antibody, Costimulatory molecule Antibody, B7H3 Antibody, B7RP-2 Antibody

May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy.

Flow Cytometry

Flow Cytometry
Mouse CD276 transfected cells stained with Rat anti-Mouse CD276:RPE This image was taken for the unconjugated form of this product. Other forms have not been tested.

Requested From: 
Date Requested: 4/24/2017

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