Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Forgot password?
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Quick Order
Products
Antibodies
ELISA and Assay Kits
Research Areas
Infectious Disease
Resources
Purchasing
Reference Material
Contact Us
Locations
Orders Processing,
Shipping & Receiving,
Warehouse
2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
Production Lab
Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
Telephone Numbers
Tel: +1 (206) 374-1102
Fax: +1 (206) 577-4565
Contact Us
Additional Contact Details
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Forgot password?
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Quick Order
CD274 / B7-H1 / PD-L1
CD274 molecule
CD274, also known as B7-H1 and PD-L1, a cell surface glycoprotein, is a member of the B7 family of co-stimulatory molecules. CD274 is expressed constitutively on macrophages and dendritic cells, and is induced on activated T-cells, B-cells, endothelial cells and epithelial cells in response to interferons. CD274 has dual functions: inhibition of activated effector T cells and co-stimulation of naïve T cells. It inhibits proliferation of activated T cells via ligation to the co-inhibitory molecule CD279 (programmed death-1; PD-1) leading to the secretion of the regulatory cytokine interleukin-10. Expression of CD274 in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma.
| Gene Name: | CD274 molecule |
| Synonyms: | CD274, B7-H, B7 homolog 1, B7-H1, B7H1, CD274 molecule, CD274 antigen, PDCD1 ligand 1, PDL1, PD-L1, PDCD1L1, PDCD1LG1, Programmed death ligand 1 |
| Target Sequences: | NM_014143 NP_054862.1 Q9NZQ7 |
Publications (19)
1
BRAF inhibition is associated with enhanced melanoma antigen expression and a more favorable tumor microenvironment in patients with metastatic melanoma. Frederick DT, Piris A, Cogdill AP, Cooper ZA, Lezcano C, Ferrone CR, Mitra D, Boni A, Newton LP, Liu C, Peng W, Sullivan RJ, Lawrence DP, Hodi FS, Overwijk WW, Lizée G, Murphy GF, Hwu P, Flaherty KT, Fisher DE, Wargo JA. Clinical cancer research : an official journal of the American Association for Cancer Research. 2013 19:1225-31. (WB; Human)
[Full Text Article]
[PubMed:23307859]
[PMC:PMC3752683]
2
Programmed cell death protein 1 and programmed death-ligand 1 are expressed on the surface of some small-cell lung cancer lines. Yamane H, Isozaki H, Takeyama M, Ochi N, Kudo K, Honda Y, Yamagishi T, Kubo T, Kiura K, Takigawa N. American journal of cancer research. 2015 5:1553-7. (Flo; Human)
[PubMed:26101718]
[PMC:PMC4473331]
3
Characterization of myeloid leukocytes and soluble mediators in pancreatic cancer: importance of myeloid-derived suppressor cells. Karakhanova S, Link J, Heinrich M, Shevchenko I, Yang Y, Hassenpflug M, Bunge H, von Ahn K, Brecht R, Mathes A, Maier C, Umansky V, Werner J, Bazhin AV. Oncoimmunology. 2015 4:e998519. (Flo; Mouse)
[Full Text Article]
[PubMed:26137414]
[PMC:PMC4485765]
☰ Filters
Products
Antibodies
(236)
Proteins
(55)
ELISA Kits
(17)
Type
Over-Expression Lysate
(2)
Primary
(236)
Recombinant
(53)
Sandwich
(15)
Sandwich CLIA
(2)
Target
CD274 / B7-H1 / PD-L1
(308)
Reactivity
Human
(194)
Mouse
(64)
Rat
(39)
Chimpanzee
(3)
Crab-eating macaque
(2)
Non-Human Primates
(2)
Orangutan
(3)
Application
IHC
(38)
IHC-Fr
(8)
IHC-P
(26)
WB
(145)
Flo
(99)
Bind
(5)
Block
(3)
ELISA
(59)
Func
(10)
ICC
(8)
ICC-IF
(1)
IF
(22)
IHC-IF
(1)
IP
(5)
Luminex
(4)
mIF
(1)
Neut
(1)
Peptide-ELISA
(3)
SDS-PAGE
(6)
Host
rabbit
(113)
mouse
(105)
goat
(3)
human
(4)
rat
(11)
Product Group
IHCPlus
(2)
PathPlus Cancer
(3)
PathPlus Cancer Pathology
(3)
Isotype
Ig
(1)
IgG
(48)
IgG,k
(1)
IgG1
(59)
IgG1,k
(6)
IgG2a,k
(5)
IgG2a,l
(2)
IgG2b
(17)
IgG2b,k
(20)
Clonality
monoclonal mc
(137)
polyclonal pc
(94)
recombinant monoclonal rmc
(5)
Clone
10F.9G2
(8)
12K56
(1)
1D7
(1)
1F11
(1)
27A2
(2)
29E.2A3
(12)
2D6
(1)
31
(1)
312
(4)
33
(1)
36
(4)
37
(1)
4F2
(1)
611
(4)
678
(1)
6D9A2
(1)
6H10
(1)
7D2A10
(1)
8E12
(2)
AHC0271
(1)
ANC6H1
(5)
G411.1
(1)
MIH3
(2)
MIH5
(2)
OR-5E3
(1)
OR-5E4
(1)
OR-5H8
(1)
OTI11G4
(2)
OTI12G7
(2)
OTI13D11
(2)
OTI13G7
(2)
OTI14H4
(2)
OTI16H9
(2)
OTI1B12
(2)
OTI20G10
(2)
OTI2B12
(2)
OTI2C11
(2)
OTI2C7
(2)
OTI2E3
(2)
OTI2F5
(2)
OTI3F5
(2)
OTI4D4
(2)
OTI4G4
(2)
OTI7D4
(2)
OTI8C8
(2)
OTI9A5
(2)
OTI9E1
(2)
OTI9E10
(2)
OTI9E12
(2)
OTI9E5
(2)
PDL1.D1
(1)
PDL1/2746
(2)
R639
(1)
RBT-PDL1
(2)
UMAB228
(2)
UMAB229
(2)
YDC 127.1.1
(2)
Format
12 x 8-Well Microstrips
(1)
96-Well Microplate
(2)
96-Well Strip Plate
(14)
APC
(5)
APC Conjugated
(15)
Azide-free
(7)
Biotin Conjugated
(16)
BSA-free
(1)
Carrier-free
(25)
Concentrated
(1)
Cy3 Conjugated
(5)
Cy5 Conjugated
(1)
Cy5.5 Conjugated
(1)
Cy7 Conjugated
(6)
FITC Conjugated
(17)
HRP Conjugated
(9)
Low Endotoxin
(2)
PE
(3)
PE Conjugated
(18)
Preservative Free
(12)
Ready-to-Use
(2)
RPE Conjugated
(1)
Unconjugated
(147)
Epitope
aa34-241
(16)
aa19-290
(12)
C-Terminus
(8)
aa24-234
(8)
aa48-290
(8)
aa261-290
(7)
aa19-239
(4)
aa192-241
(4)
PDL1
(2)
aa19-238
(2)
Internal
(1)
aa166-176
(1)
aa45-290
(1)
Publications
No
(304)
Yes
(4)
Sample Type
Cell Culture Supernatants
(6)
Cell Lysates
(4)
Plasma
(15)
Serum
(15)
Tissue Homogenates
(8)
Tag
6His, C-terminus
(5)
DDK (Flag)-His, C-terminus
(1)
DDK,C-terminus
(3)
Fc, C-terminus
(9)
Fc-AVI, C-terminus
(1)
Flag,C-terminus
(1)
GST, N-terminus
(1)
His
(4)
His,C-terminus
(7)
His-GST
(1)
His-T7
(3)
Human IgG Fc, C-terminus
(1)
Human IgG1 Fc
(1)
Human Mutant IgG1 Fc
(1)
mFc, C-terminus
(2)
Mouse IgG1 Fc, C-terminus
(1)
Mouse IgG2 Fc
(1)
Mouse IgG2a Fc, N-terminus
(1)
Mouse Mutant IgG2a Fc
(1)
Myc-DDK (Flag)
(2)
Species
Crab-eating macaque
(2)
Human
(36)
Mouse
(13)
Rat
(3)
Source
293T Cells
(1)
CHO Cells
(9)
E. coli
(7)
HEK 293 Cells
(17)
Human Cells
(7)
Mammalian Cells
(11)
Sf9 Cells
(2)
Wheat Germ Extract
(1)
Purification
Purified
(11)
Low Endotoxin Level
Low endotoxin level
(36)
Biologically Active
Biologically active
(10)
CD274 / B7-H1 / PD-L1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
CD274 / B7-H1 / PD-L1 Mouse anti-Human Monoclonal (OTI2C7) Antibody
Human
IF, WB
Unconjugated
100 µl/$434
CD274 / B7-H1 / PD-L1 Mouse anti-Human Monoclonal (PE) (27A2) Antibody
Human
Flo
PE Conjugated
1 ml/$430
CD274 / B7-H1 / PD-L1 Rabbit anti-Human Polyclonal (aa261-290) Antibody
Human
IHC, IHC-P, WB
Unconjugated
200 µl/$460
CD274 / B7-H1 / PD-L1 Rat anti-Mouse Monoclonal (MIH5) Antibody
Mouse
Flo, IHC, IHC-Fr
Unconjugated
100 µg/$305
CD274 / B7-H1 / PD-L1 Mouse anti-Human Monoclonal (27A2) Antibody
Human
Flo, IHC, IHC-P
Unconjugated
100 µg/$430
CD274 / B7-H1 / PD-L1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
CD274 / B7-H1 / PD-L1 Mouse anti-Human Monoclonal (ANC6H1) Antibody
Human
ELISA, Flo
Unconjugated
100 µg/$446
CD274 / B7-H1 / PD-L1 Mouse anti-Human Monoclonal (Biotin) (ANC6H1) Antibody
Human
ELISA, Flo
Biotin Conjugated
100 µg/$536
CD274 / B7-H1 / PD-L1 Mouse anti-Human Monoclonal (Azide-free) (ANC6H1) Antibody
Human
ELISA, Flo
Unconjugated, Azide-free
100 µg/$446
CD274 / B7-H1 / PD-L1 Rabbit anti-Human Recombinant Monoclonal (RBT-PDL1) Antibody
Human
IHC, IHC-Fr, IHC-P
Unconjugated
0.1 ml/$448; 0.5 ml/$941; 1 ml/$1,288
CD274 / B7-H1 / PD-L1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$393
CD274 / B7-H1 / PD-L1 Rabbit anti-Mouse Polyclonal (aa34-241) Antibody
Mouse
WB
Unconjugated
100 µl/$301; 200 µl/$340; 500 µl/$470; 1 ml/$535; 2 ml/$698; 5 ml/$1,161
CD274 / B7-H1 / PD-L1 Mouse anti-Human Monoclonal (MIH3) Antibody
Flo
Unconjugated
100 µg/$430
CD274 / B7-H1 / PD-L1 Rabbit anti-Rat Polyclonal (aa34-241) Antibody
Rat
WB
Unconjugated
100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206
CD274 / B7-H1 / PD-L1 Rabbit anti-Rat Polyclonal (aa34-241) (Biotin) Antibody
Rat
WB
Biotin Conjugated
100 µl/$316; 200 µl/$361; 500 µl/$511; 1 ml/$587; 2 ml/$809; 5 ml/$1,317
CD274 / B7-H1 / PD-L1 Rabbit anti-Rat Polyclonal (aa34-241) (PE) Antibody
Rat
WB
PE Conjugated
100 µl/$402; 200 µl/$484; 500 µl/$834; 1 ml/$991; 2 ml/$1,277; 5 ml/$2,395
CD274 / B7-H1 / PD-L1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, Flo, IF, WB
Unconjugated
0.1 mg/$460
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$782
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$764
Cancer Pathology
Cancer
CD274 / B7-H1 / PD-L1 Rabbit anti-Human Monoclonal (AHC0271) Antibody
Human
IHC-P
Unconjugated
0.05 ml/$440
CD274 / B7-H1 / PD-L1 Mouse anti-Human Monoclonal Antibody
Human
IF, IHC-P, WB
Unconjugated
100 µg/$351
Viewing 1-25
of 308
product results
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.
