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CD22

CD22 molecule

Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.

Gene Name: CD22 molecule
Family/Subfamily: Immunoglobulin , not assigned-Immunoglobulin
Synonyms: CD22, CD22 molecule, CD22 antigen, SIGLEC2, SIGLEC-2, T-cell surface antigen Leu-14, B-cell receptor CD22, BL-CAM
Target Sequences: NM_001771 NP_001762.2 P20273

Publications (1)

1
Epitope mapping and key amino acid identification of anti-CD22 immunotoxin CAT-8015 using hybrid -lactamase display. Bannister D, Popovic B, Sridharan S, Giannotta F, File P, Yilmaz N, Minter R. Protein engineering, design & selection : PEDS. 2011 24:351-60. (IP) [PubMed:21159620] [PMC:PMC3049344]

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CD22 Antibody - Anti-CD22 antibody IHC staining of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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CD22 Mouse anti-Human Monoclonal (1B1) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
CD22 Antibody - IHC of paraffin-embedded Human lymph node tissue using anti-CD22 mouse monoclonal antibody.
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CD22 Mouse anti-Human Monoclonal (OTI4C3) Antibody
Mouse, Dog, Rat, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100 µl/$434
CD22 Antibody - Flow cytometry of CD22 antibody
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CD22 Mouse anti-Human Monoclonal (RFB4) Antibody
Human
Flo, IHC, IHC-P
Unconjugated
100 µg/$411
CD22 Antibody - Flow cytometry of CD22 antibody This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CD22 Mouse anti-Human Monoclonal (Biotin) (RFB4) Antibody
Human
Flo, IHC, IHC-P
Biotin Conjugated
100 µg/$446
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CD22 Mouse anti-Human Monoclonal (FITC) (RFB4) Antibody
Human
Flo, IHC, IHC-P
FITC Conjugated
120 Tests/$446
CD22 Antibody - Flow-cytometry on rhesus monkey lymphocytes.
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CD22 Human anti-Human Recombinant Monoclonal (CD22) (hL22 (Epratuzumab)) Antibody
Human, Monkey-Cynomolgus, Monkey-Rhesus
Block, Flo, IP
Unconjugated
0.2 mg/$540
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CHO Cells
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
75.0 kDa
5 µg/$268; 20 µg/$349
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CD22 Mouse anti-Human Monoclonal (APC) (IS7) Antibody
Human
Flo
APC Conjugated
100 Tests/$411
CD22 Antibody - Surface staining of CD22 in human peripheral blood cells with anti-CD22 (IS7) azide free, GAM-APC.
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CD22 Mouse anti-Human Monoclonal (Azide-free) (IS7) Antibody
Human
Flo
Unconjugated, Azide-free
0.1 mg/$330
CD22 Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
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CD22 Mouse anti-Human Monoclonal (aa707-847) (2B12) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
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CD22 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, WB
HRP Conjugated
100 µl/$842
CD22 Antibody - Flow cytometry of CD22 antibody This image was taken for the unmodified form of this product. Other forms have not been tested.
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CD22 Mouse anti-Human Monoclonal (Azide-free) (RFB4) Antibody
Human
Flo, IHC, IHC-P
Unconjugated, Azide-free
100 µg/$411
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CD22 Mouse anti-Human Monoclonal (MEM-01) Antibody
Human, Non-Human Primates
Flo, IP, WB
Unconjugated
0.1 mg/$302
CD22 Antibody - Surface staining of human peripheral blood cells with anti-CD22 (MEM-01) biotin / streptavidin-APC.
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CD22 Mouse anti-Human Monoclonal (Biotin) (MEM-01) Antibody
Human, Non-Human Primates
Flo, IP, WB
Biotin Conjugated
0.1 mg/$337
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CD22 Mouse anti-Human Monoclonal (MYG13) Antibody
Mouse, Rat, Human
ELISA, Flo, IF, IHC, IHC-Fr, IP
Unconjugated
100 µg/$567; 1 mg/$1,079
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CD22 Rabbit anti-Mouse Monoclonal (APC) (060) Antibody
Mouse
Flo
APC Conjugated
25 Tests/$278; 100 Tests/$376
CD22 Antibody -  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CD22 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
ICC, IHC, IHC-Fr, IHC-P, WB
Unconjugated
100 µg/$380
CD22 Antibody - Western blot analysis of extracts of various cell lines, using CD22 antibody.
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CD22 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
CD22 Antibody - CD22 antibody. IHC(P): Human Tonsil Tissue.
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CD22 Rabbit anti-Human Polyclonal (aa832-847) Antibody
Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
CD22 Antibody - Human peripheral blood lymphocytes stained with purified HIB22, followed by anti-mouse IgGs FITC
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CD22 Mouse anti-Human Monoclonal (HIB22) Antibody
Human
Flo, IHC, IHC-Fr
Unconjugated
100 µg/$285
CD22 Antibody - CD22 antibody IHC-paraffin. IHC(P): Human Tonsil Tissue.
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CD22 Rabbit anti-Human Polyclonal (aa696-724) Antibody
Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
Select
CD22 Mouse anti-Human Monoclonal (N-Terminus) (MEM-01) Antibody
Human
Flo, IP, WB
Unconjugated
0.2 mg/$471
CD22 Antibody - IHC of paraffin-embedded Human tonsil using anti-CD22 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min)(1:150).
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CD22 Mouse anti-Human Monoclonal (aa707-847) (OTI2E6) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
Select
CD22 Rat anti-Mouse Monoclonal (2D6) Antibody
Mouse
Flo, IP
Unconjugated
500 µg/$718
CD22 Antibody - IHC of paraffin-embedded cervical cancer tissues using ZEB1 mouse monoclonal antibody with DAB staining.
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CD22 Mouse anti-Human Monoclonal (aa621-725) (2H1C4) Antibody
Human
ELISA, Flo, IF, IHC, WB
Unconjugated
100 µl/$459
Viewing 1-25 of 218 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).