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Anti-CD209 / DC-SIGN Antibody (clone MR-1, FITC) LS-C188284

Ordering

Wt. Vol. Conc. Price
100 µg - 0.1 mg/ml $480
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular CD209 / DC-SIGN Antibodies

Anti-CD209 / DC-SIGN Antibody (Internal) IHC-plus™ LS-B479
Rabbit Polyclonal to Human CD209 / DC-SIGN
Human
IHC - Paraffin, Western blot
Unconjugated
Immunohistochemistry Image
Anti-CD209 / DC-SIGN Antibody (clone LWC06, APC) LS-C106997
Rat Monoclonal [clone LWC06] (IgG2a) to Mouse CD209 / DC-SIGN
Mouse
Flow Cytometry
APC Conjugated
Flow Cytometry Image
Anti-CD209 / DC-SIGN Antibody (clone h209) IHC-plus™ LS-B3782
Rat Monoclonal [clone h209] (IgG2a,k) to Human CD209 / DC-SIGN
Human
IHC - Paraffin, Immunoprecipitation, Flow Cytometry
Unconjugated
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed
Mouse Monoclonal [clone MR-1] (IgG1) to Human CD209 / DC-SIGN
Human
Immunofluorescence, Flow Cytometry (applications tested for the base form of this product only)
FITC Conjugated

Details

Human CD209 / DC-SIGN
Mouse
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [MR-1]
Fluorescein. Also available Unconjugated or conjugated with RPE.
Protein G purified
Unmodified

Applications

  • Immunofluorescence
  • Flow Cytometry (1:1 - 1:5)
  • (applications tested for the base form of this product only)

Specificity and Use

CD209 / DC-SIGN antibody was raised against immature myeloid monocyte-derived dendritic cells (MDDCs).
Recognizes human DC-specific ICAM-3 grabbing nonintegrin (DC-SIGN), a 45kD C-type lectin that binds ICAM-3 which is also known as CD209. CD209 is primarily expressed on a population of immature dendritic cells in peripheral tissues and on immature myeloid monocyte-derived DC's in vitro. CD209 is involved in dendritic cell (DC) migration and the initial interaction between DC's and naive T lymphocytes. CD209 also binds HIV-1 gp120 and plays a key role in the dissemination of HIV-1 by DC's. Clone MR-1 is reported to partially block the functional activity of DC-SIGN.
The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.

Packaging

PBS, 0.09% sodium azide, 1% BSA
Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles. Protect from light.
For research use only.

About CD209 / DC-SIGN

Q9NNX6 NM_021155 NP_066978.1

CD209 Antibody, CD209 antigen Antibody, CD209 molecule Antibody, CDSIGN Antibody, CLEC4L Antibody, DC-SIGN Antibody, HIV gpl20-binding protein Antibody, DC-SIGN1 Antibody

Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response.

Flow Cytometry

Flow Cytometry
Flow cytometry of CD209 transfected K562 cells with Mouse anti-Human CD209: FITC This image was taken for the unconjugated form of this product. Other forms have not been tested.

Flow Cytometry

Flow Cytometry
Flow cytometry of CD209 transfected K562 cells with Mouse anti-Human CD209. This image was taken for the unmodified form of this product. Other forms have not been tested.

Requested From: United States
Date Requested: 12/7/2016

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