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CD209 / DC-SIGN

CD209 molecule

Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens, including HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, cytomegalovirus gB, HCV E2, dengue virus gE, Leishmania pifanoi LPG, Lewis-x antigen in Helicobacter pylori LPS, mannose in Klebsiella pneumonae LPS, di-mannose and tri-mannose in Mycobacterium tuberculosis ManLAM and Lewis-x antigen in Schistosoma mansoni SEA.On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells.

Gene Name: CD209 molecule
Synonyms: CD209, CD209 antigen, CD209 molecule, CDSIGN, CLEC4L, DC-SIGN, HIV gpl20-binding protein, DC-SIGN1
Target Sequences: NM_021155 NP_066978.1 Q9NNX6

Publications (2)

1
A method for manual and automated multiplex RNAscope in situ hybridization and immunocytochemistry on cytospin samples. Sara Chan, Audrey Filézac de L'Etang, Linda Rangell, Patrick Caplazi, John B Lowe, Valentina Romeo. PloS one. 2018 Nov;13:e0207619. [Full Text Article] [PubMed:30458053] [PMC:PMC6245747] Related Antibodies: LS-B3782.
2
Single-cell RNA sequencing uncovers the individual alteration of intestinal mucosal immunocytes in Dusp6 knockout mice. Cherng-Shyang Chang, Wen-Hsuan Yu, Chang-Chao Su, Jhen-Wei Ruan, Chiao-Mei Lin, Chih-Ting Huang, Yi-Ting Tsai, I-Jung Lin, Chao-Yang Lai, Tsung-Hsien Chuang, Wen-Jye Lin, Tse-Hua Tan, Hsuan-Cheng Huang, Hsueh-Fen Juan, Cheng-Yuan Kao. iScience. 2022 February;25:103738. [Full Text Article] [PubMed:35128351] [PMC:PMC8800014] Related Antibodies: LS-C782089.

☰ Filters
Antibodies (101)
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CD209 / DC-SIGN Antibody - Anti-CD209 / DC-SIGN antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
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CD209 / DC-SIGN Rat anti-Human Monoclonal (h209) Antibody
Human
Flo, IHC, IHC-P, IP
Unconjugated
50 µg/$460
CD209 / DC-SIGN Antibody - Anti-CD209 / DC-SIGN antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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CD209 / DC-SIGN Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
CD209 / DC-SIGN Antibody - IHC testing of FFPE human intestinal cancer tissue with DC-SIGN antibody at 1ug/ml. Required HIER: steam section in pH6 citrate buffer for 20 min and allow to cool prior to staining.
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CD209 / DC-SIGN Rabbit anti-Human Polyclonal Antibody
Human
Flo, IHC-P, WB
Unconjugated
100 µg/$575
CD209 / DC-SIGN Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
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CD209 / DC-SIGN Mouse anti-Human Monoclonal (8B6) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
CD209 / DC-SIGN Protein - Recombinant  C-Type Lectin Domain Family 4, Member L By SDS-PAGE
Select
E. coli
His, N-Terminal
42.0 kDa
10 µg/$275; 50 µg/$407; 100 µg/$652; 200 µg/$812; 1 mg/$1,893; 500 µg/$1,444; 5 mg/$2,843; 2 mg/$2,077
CD209 / DC-SIGN Antibody - CIRE-transfected CHO cells were surface stained with 0.5 ug PE rat IgG2a isotype control (open histogram) or PE anti-mouse CIRE (5H10) (colored histogram). Splenocytes shown are gated on CD11C+ cells. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CD209 / DC-SIGN Rat anti-Mouse Monoclonal (PE) (5H10) Antibody
Mouse
Flo
PE Conjugated
25 µg/$300
CD209 / DC-SIGN Protein - Recombinant  C-Type Lectin Domain Family 4, Member L By SDS-PAGE
Select
E. coli
His-T7
18.0 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
CD209 / DC-SIGN Antibody - Immunohistochemistry of DC-SIGN in human small intestine tissue with DC-SIGN antibody at 10 µg/ml.
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CD209 / DC-SIGN Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
0.1 mg/$460
CD209 / DC-SIGN Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
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CD209 / DC-SIGN Mouse anti-Human Monoclonal (5D7) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
0.1 mg/$485
CD209 / DC-SIGN Antibody - Western blot of CD209 / DC-SIGN antibody.
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CD209 / DC-SIGN Rabbit anti-Mouse Polyclonal (aa115-238) Antibody
Mouse
WB
Unconjugated
100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206
CD209 / DC-SIGN Antibody - Immunohistochemistry - Anti-DC-SIGN Picoband antibody
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CD209 / DC-SIGN Rabbit anti-Human Polyclonal Antibody
Human
Flo, ICC, IHC, IHC-Fr, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
CD209 / DC-SIGN Antibody - Immunohistochemistry of paraffin-embedded human lung tissue at dilution of 1:100
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CD209 / DC-SIGN Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
CD209 / DC-SIGN Antibody - Flow cytometric analysis of Human CD209 expression on DC. Cells were stained with purified anti-Human CD209, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
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CD209 / DC-SIGN Rabbit anti-Human Monoclonal (Preservative Free) (037) Antibody
Human
Flo
Unconjugated, Preservative Free
100 µl/$412
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CD209 / DC-SIGN Rabbit anti-Human Monoclonal (Preservative Free) (059) Antibody
Human
ELISA
Unconjugated, Preservative Free
20 µl/$271; 100 µl/$412
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CD209 / DC-SIGN Mouse anti-Human Monoclonal Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
100 µg/$962
CD209 / DC-SIGN Antibody - Flow cytometric analysis of Human CD209 expression on DC. Cells were stained with APC-conjugated anti-Human CD209. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
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CD209 / DC-SIGN Rabbit anti-Human Monoclonal (APC) (037) Antibody
Human
Flo
APC Conjugated
25 Tests/$278; 100 Tests/$421
CD209 / DC-SIGN Antibody - Flow cytometric analysis of Human CD209 expression on DC. Cells were stained with PE-conjugated anti-Human CD209. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
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CD209 / DC-SIGN Rabbit anti-Human Monoclonal (PE) (037) Antibody
Human
Flo
PE Conjugated
25 Tests/$278; 100 Tests/$376
CD209 / DC-SIGN Antibody - Flow cytometric analysis of Human CD209 expression on DC. Cells were stained with FITC-conjugated anti-Human CD209. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
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CD209 / DC-SIGN Rabbit anti-Human Monoclonal (FITC) (037) Antibody
Human
Flo
FITC Conjugated
25 Tests/$263; 100 Tests/$323
CD209 / DC-SIGN Antibody - IHC testing of FFPE human lung carcinoma with DC-SIGN antibody (clone C209/1781). Required HIER: boil tissue sections in 10mM Tris with 1mM EDTA, pH 9, for 10-20.
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CD209 / DC-SIGN Mouse anti-Human Monoclonal (C209/1781) Antibody
Human
Flo, IF, IHC-P
Unconjugated
20 µg/$371; 100 µg/$574
CD209 / DC-SIGN Antibody - IHC testing of FFPE human lung carcinoma with DC-SIGN antibody (clone C209/1781). Required HIER: boil tissue sections in 10mM Tris with 1mM EDTA, pH 9, for 10-20.
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CD209 / DC-SIGN Mouse anti-Human Monoclonal (Azide-free, BSA-free) (C209/1781) Antibody
Human
Flo, IF, IHC-P
Unconjugated, Azide-free, BSA-free
100 µg/$574
Select
CD209 / DC-SIGN Mouse anti-Human Monoclonal (UW60.1) Antibody
Human
Flo, ICC, IHC
Unconjugated
0.1 mg/$302
CD209 / DC-SIGN Antibody - Surface staining of human monocytes-derived dendritic cells with anti-human CD209 (UW60.1) APC.
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CD209 / DC-SIGN Mouse anti-Human Monoclonal (APC) (UW60.1) Antibody
Human
Flo, ICC, IHC
APC Conjugated
100 Tests/$365
CD209 / DC-SIGN Antibody - Surface staining of human monocytes-derived dendritic cells with anti-human CD209 (UW60.1) PE.
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CD209 / DC-SIGN Mouse anti-Human Monoclonal (PE) (UW60.1) Antibody
Human
Flo, ICC, IHC
PE Conjugated
100 Tests/$365
Select
CD209 / DC-SIGN Mouse anti-Human Monoclonal (5C2A6) Antibody
Human
ELISA, Flo, WB
Unconjugated
100 µl/$459
Select
CD209 / DC-SIGN Mouse anti-Human Monoclonal (5C2G9) Antibody
Human
ELISA, Flo, WB
Unconjugated
100 µl/$459
Viewing 1-25 of 112 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).