(tested or 100% immunogen sequence identity)
Protein A purified
- IHC - Frozen
- Western blot
- Flow Cytometry (1:1000)
- Functional Assay
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CD1D antibody was raised against rat CD1d-transduced M12.4.1. C3 cells.
Recognizes rat CD1d, a glycoprotein expressed on cortical thymocytes, certain T-cell leukemias and various other antigen presenting cells. CD1d binds self and non-self glycolipids and presents them to T-cell receptors on natural killer cells. When activated, natural killer cells produce Th1 and Th2 cytokines. Clone WTH1 recognizes a different, non-overlapping epitope than clone WTH2 (, or ), and binds with high affinity to the mature CD1d heavy chain independently of beta-2-microglobulin. Clone WTH1 efficiently blocks rat and mouse invariant natural killer T cell (iNKT cell) response to a-GalCer (an antigen for iNKT cells) and has a slightly higher affinity to native CD1d than clone WTH2. Clone WTH1 cross reacts weakly with mouse tissue in IHC and western blotting, but reacts strongly with both rat and mouse antigens in flow cytometry and immunoprecipitation.
The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.
PBS, 0.02% sodium azide
4°C or -20°C, Avoid freeze-thaw cycles.
For research use only.
This antibody carries the LSBio 100% Guarantee.