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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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CD163 Antibody (clone 2A10/11, RPE) LS‑C188274
CD163 antibody LS-C188274 is an RPE-conjugated mouse monoclonal antibody to pig CD163. Validated for Flow, IF, IHC, IP and WB.
Catalog
Size
Price
LS-C188274-100
100 tst
Unavailable

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Product Description

CD163 antibody LS-C188274 is an RPE-conjugated mouse monoclonal antibody to pig CD163. Validated for Flow, IF, IHC, IP and WB.
About CD163
Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Q86VB7 NM_004244 NP_004235.4

CD163 Antibody, CD163 antigen Antibody, Macrophage-associated antigen Antibody, M130 Antibody, CD163 molecule Antibody, Hemoglobin scavenger receptor Antibody, MM130 Antibody


Specifications

Target
Pig CD163
Host
Mouse
Reactivity
Pig (tested or 100% immunogen sequence identity)
Clonality
IgG1 Monoclonal [2A10/11]
Conjugations
R. Phycoerythrin. Also available Unconjugated or conjugated with FITC.
Purification
Protein G purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Frozen
  • Immunofluorescence
  • Western blot
  • Immunoprecipitation
  • Flow Cytometry (1:1 - 1:10)
  • (applications tested for the base form of this product only)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
CD163 antibody was raised against porcine alveolar macrophages.
Specificity
Recognizes porcine CD163, a 120kD cell surface glycoprotein that is expressed on cells of the monocyte/macrophage lineage. The expression levels of CD163 vary during the course of macrophage differentiation. The highest levels of CD163 expression are found on tissue macrophages but bone marrow derived cells are CD163 negative. Expression of CD163 on peripheral blood monocytes varies between about 5% and 50% depending on the donor. Clone is reported to inhibit both African swine fever infection and viral particle binding to alveolar macrophages in a dose-dependent manner.
Usage
The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.
Presentation
PBS, 0.09% sodium azide, 1% BSA, 5% sucrose
Reconstitution
100 tst Distilled water
Storage
Short term: store at 4°C. Long term: -20°C. Avoid freeze-thaw cycles. Protect from light.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Images


Flow Cytometry

Flow cytometry of porcine peripheral blood mononuclear cells with Mouse anti-Porcine CD163.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Flow cytometry of porcine peripheral blood mononuclear cells with Mouse anti-Porcine CD163. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Flow Cytometry

Flow cytometry of porcine peripheral blood mononuclear cells with Mouse anti-Porcine CD163.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Flow cytometry of porcine peripheral blood mononuclear cells with Mouse anti-Porcine CD163. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Flow Cytometry

Flow cytometry of porcine peripheral blood mononuclear cells with Mouse anti-Porcine CD163.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Flow cytometry of porcine peripheral blood mononuclear cells with Mouse anti-Porcine CD163. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Flow Cytometry

Flow cytometry of porcine peripheral blood mononuclear cells with Mouse anti-Porcine CD163.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Flow cytometry of porcine peripheral blood mononuclear cells with Mouse anti-Porcine CD163. This image was taken for the unconjugated form of this product. Other forms have not been tested.


Requested From: 
Date Requested: 6/17/2018

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