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CD135 / FLT3
fms-related tyrosine kinase 3
Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.
| Gene Name: | fms-related tyrosine kinase 3 |
| Family/Subfamily: | Protein Kinase , PDGF Receptor |
| Synonyms: | FLT3, CD135, CD135 antigen, Fetal liver kinase 2, Fetal liver kinase-2, FL cytokine receptor, FLK2, FLT-3, Fms-like tyrosine kinase 3, Stem cell tyrosine kinase 1, STK-1, FLK-2, Fms-related tyrosine kinase 3, STK1 |
| Target Sequences: | NM_004119 NP_004110.2 P36888 |
Publications (1)
1
Alphavirus Replicon Particle Vaccine Breaks B Cell Tolerance and Rapidly Induces IgG to Murine Hematolymphoid Tumor Associated Antigens. Hsuan Su, Kazuhiro Imai, Wei Jia, Zhiguo Li, Rachel A DiCioccio, Jonathan S Serody, Jonathan C Poe, Benny J Chen, Phuong L Doan, Stefanie Sarantopoulos. Frontiers in immunology. 2022 June;13:865486. [Full Text Article]
[PubMed:35686131]
[PMC:PMC9171395]
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Fast Shipping
CD135 / FLT3 Rabbit anti-Human Polyclonal (Internal) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$440
Fast Shipping
CD135 / FLT3 Rabbit anti-Human Polyclonal Antibody
Rabbit, Dog, Pig, Horse, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
CD135 / FLT3 Rat anti-Mouse Monoclonal (A2F10) Antibody
Mouse
Flo, IP
Unconjugated
500 µg/$412
CD135 / FLT3 Mouse anti-Human Monoclonal (BV10A4) Antibody
Human
Flo, IP
Unconjugated
0.1 mg/$302
CD135 / FLT3 Mouse anti-Human Monoclonal (FITC) (BV10A4) Antibody
Human
Flo, IP
FITC Conjugated
100 Tests/$337
CD135 / FLT3 Mouse anti-Human Monoclonal (aa169-444) (OTI7D6) Antibody
Human
WB
Unconjugated
100 µl/$434
Mammalian Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
85.3 kDa
10 µg/$354; 50 µg/$425
CD135 / FLT3 Rabbit anti-Human Polyclonal (pTyr591) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$689
CD135 / FLT3 Rabbit anti-Human Polyclonal (aa33-64) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
CD135 / FLT3 Mouse anti-Human Monoclonal (1A11) Antibody
Human
ELISA
Unconjugated
200 µl/$423
CD135 / FLT3 Rabbit anti-Human Polyclonal (pTyr591) Antibody
Mouse, Human, Monkey
ELISA, IHC, WB
Unconjugated
50 µg/$489
CD135 / FLT3 Rabbit anti-Human Polyclonal (aa33-64) Antibody
Human
ELISA, Flo, WB
Unconjugated
200 µl/$734
CD135 / FLT3 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$440
CD135 / FLT3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
Fast Shipping
CD135 / FLT3 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
Sandwich
96-Well Microplate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
Sandwich
96-Well Strip Plate
Mouse
78.125 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CD135 / FLT3 Rabbit anti-Human Polyclonal (pTyr969) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
CD135 / FLT3 Mouse anti-Human Monoclonal (pTyr591) Antibody
Human
WB
Unconjugated
100 µl/$689
CD135 / FLT3 Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA, IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
CD135 / FLT3 Mouse anti-Human Monoclonal (aa930-991) (7B7C3) Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µl/$459
Sandwich
96-Well Strip Plate
Human
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$758
Human Cells
His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
59.7 kDa
100 µg/$926; 1 mg/$4,701
CD135 / FLT3 Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF, IHC-P
Unconjugated
100 µl/$412
CD135 / FLT3 Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$250; 60 µl/$286; 120 µl/$349; 200 µl/$439
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