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CD121b / IL1R2
interleukin 1 receptor, type II
Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.
| Gene Name: | interleukin 1 receptor, type II |
| Family/Subfamily: | Interleukin |
| Synonyms: | IL1R2, CD121b, CD121b antigen, CDw121b, IL-1RT-2, IL1R2c, Interleukin-1 receptor beta, Interleukin-1 receptor type II, IL-1R-beta, Antigen CDw121b, IL-1 type II receptor, IL-1R-2, IL-1RT2, IL1RB, Interleukin-1 receptor type 2 |
| Target Sequences: | NM_004633 NP_004624.1 P27930 |
Publications (1)
1
Altered activation state of circulating neutrophils in patients with neovascular age-related macular degeneration. Marie Krogh Nielsen, Sven Magnus Hector, Kelly Allen, Yousif Subhi, Torben Lykke Sørensen. Immunity & ageing : I & A. 2017 Jul;14:18. [Full Text Article]
[PubMed:28769990]
[PMC:PMC5531023]
Related Antibodies: LS-C139986.
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CD121b / IL1R2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, Flo, IHC, IHC-P, IP, RIA, WB
Unconjugated
0.05 mg/$795
CD121b / IL1R2 Rabbit anti-Mouse Monoclonal (Preservative Free) (016) Antibody
Mouse
ELISA
Unconjugated, Preservative Free
100 µl/$412
CD121b / IL1R2 Mouse anti-Human Monoclonal (aa14-343) (PE) Antibody
Human
Flo
PE Conjugated
100 Tests/$860
Sandwich
96-Well Strip Plate
Mouse
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$782
CD121b / IL1R2 Mouse anti-Human Monoclonal (MNC2) Antibody
Human
ELISA, Flo, WB
Unconjugated
100 µg/$832
CD121b / IL1R2 Mouse anti-Human Monoclonal (8.5) Antibody
Human
Flo, WB
Unconjugated
100 µg/$554
CD121b / IL1R2 Mouse anti-Human Monoclonal (FITC) (8.5) Antibody
Human
Flo, WB
FITC Conjugated
100 µg/$617
CD121b / IL1R2 Rabbit anti-Human Polyclonal (aa20-320) Antibody
Mouse, Human
ELISA, WB
Unconjugated
50 µl/$294; 100 µl/$360
CD121b / IL1R2 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µl/$299
CD121b / IL1R2 Rabbit anti-Human Polyclonal (aa172-398) Antibody
Human
ICC, IHC, IHC-P, WB
Unconjugated
100 µl/$450
CD121b / IL1R2 Rabbit anti-Human Monoclonal (Preservative Free) (041) Antibody
Human
ELISA
Unconjugated, Preservative Free
20 µl/$271; 100 µl/$412
CD121b / IL1R2 Rabbit anti-Human Polyclonal (Biotin) Antibody
Mouse, Human
WB
Biotin Conjugated
100 µl/$937
CD121b / IL1R2 Rabbit anti-Rat Monoclonal (Preservative Free) (161) Antibody
Rat
ELISA
Unconjugated, Preservative Free
20 µl/$271; 100 µl/$412
CD121b / IL1R2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CD121b / IL1R2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, Flo, IP, RIA, WB
Unconjugated
100 µg/$567
CD121b / IL1R2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, Flo, IP, RIA, WB
Unconjugated
25 µl/$304
Sandwich
96-Well Microplate
Mouse
78.125 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
Sandwich
96-Well Strip Plate
Human
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Serum
1 Plate/$717
CD121b / IL1R2 Rabbit anti-Human Polyclonal Antibody
Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
CD121b / IL1R2 Mouse anti-Human Monoclonal Antibody
Human
Flo, WB
Unconjugated
100 µg/$826
CD121b / IL1R2 Mouse anti-Human Monoclonal (Concentrated) (8.5) Antibody
Human
Flo, WB
Unconjugated, Concentrated
1 ml/$638
CD121b / IL1R2 Rabbit anti-Human Polyclonal Antibody
Human, Primate
ELISA, IP, WB
Unconjugated
1 ml/$1,225
CD121b / IL1R2 Rabbit anti-Human Polyclonal Antibody
Human, Primate
ELISA, IP, WB
Unconjugated
100 µl/$567
CD121b / IL1R2 Rabbit anti-Human Polyclonal Antibody
Human, Primate
ELISA, IP, WB
Unconjugated
25 µl/$304
CD121b / IL1R2 Mouse anti-Human Monoclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$351
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