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Anti-CD119 / IFNGR1 Antibody (aa18-245) LS-C149974

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Wt. Vol. Conc. Price
100 µg - - $395
Inquire for larger quantities

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Goat Polyclonal (IgG) to Human CD119 / IFNGR1
Human
ICC, Western blot, Neutralization
Unconjugated

Details

Human CD119 / IFNGR1
Goat
Human (tested or 100% immunogen sequence identity)
IgG Polyclonal
Unconjugated
Immunoaffinity purified
Unmodified

Applications

  • ICC (5 - 15 µg/ml)
  • Western blot (0.1 µg/ml)
  • Neutralization

Specificity and Use

CD119 / IFNGR1 antibody was raised against mouse myeloma cell line NS0-derived recombinant human IFNgamma R1/CD119 Glu18-Gly245 Accession # P15260.
aa18-245
Detects IFN gamma R1/CD119 in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 1% cross-reactivity with.
Western Blot, 0.1 µg/ml, Recombinant Human IFN-gamma R1/CD119. Immunocytochemistry, 5-15 µg/ml, Immersion fixed human peripheral blood mononuclear cells. Neutralization, Measured by its ability to neutralize IFN-gamma R1/CD119-mediated inhibition of EMCV-induced cytopathy in the HeLa. Human cervical epithelial carcinoma cell line. The Neutralization Dose (ND50) is typically 0.5-2 µg/ml in the presence of 2 ng/ml Recombinant Human IFN-gamma.

Packaging

Lyophilized from 0.2 um filtered solution in PBS, trehalose
Sterile PBS. Resuspend to 500 ul
Store lyophilized at 4°C. Once reconstituted, aliquot and store at -20°C. Avoid freeze-thaw cycles.
For research use only.

About CD119 / IFNGR1

P15260 NM_000416 NP_000407.1

IFNGR1 Antibody, AVP, type 2 Antibody, Antiviral protein, type 2 Antibody, CD119 Antibody, CD119 antigen Antibody, IFNGR Antibody, IFN-gamma receptor 1 Antibody, IFN-gamma-R1 Antibody, Immune interferon receptor 1 Antibody, Interferon gamma receptor 1 Antibody, CDw119 Antibody

This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection.

Neutralization

Neutralization
IFN- gamma Inhibition of EMCV-induced Cytopathy and Neutralization by Human IFN- gamma R1/CD119 Antibody. Recombinant Human IFN- gamma reduces the Encephalomyocarditis Virus (EMCV)-induced cytopathy in the HeLa human cervical epithelial carcinoma cell line in a dose-dependent manner (orange line). Inhibition of EMCV activity elicited by Recombinant Human IFN- gamma (2 ng/ml) is neutralized (green line) by increasing concentrations of Goat Anti-Human IFN- gamma R1/CD119 Antigen Affinity-purified Polyclonal Antibody. The ND50 is typically 0.5-2 ug/ml.
 

Requested From: United States
Date Requested: 12/2/2016

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