CD110 / MPL

myeloproliferative leukemia virus oncogene

In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.

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Products

Antibodies (36)

Proteins (8)

ELISA Kits (3)

Type

Over-Expression Lysate (2)

Primary (36)

Recombinant (6)

Sandwich (3)

Target

CD110 / MPL (47)

Reactivity

Human (37)

Mouse (15)

Rat (3)

Hamster (1)

Monkey (1)

Application

IHC (2)

IHC-P (1)

WB (31)

Flo (4)

ELISA (9)

IF (1)

IP (1)

Host

rabbit (32)

mouse (4)

Isotype

Ig (2)

IgG (13)

IgG2a (2)

IgG2b (2)

Clonality

monoclonal mc (4)

polyclonal pc (32)

Clone

1D6B7 (1)

1H2 (2)

Format

96-Well Strip Plate (3)

APC (2)

APC Conjugated (3)

Biotin Conjugated (4)

Cy3 Conjugated (2)

Cy7 Conjugated (2)

FITC Conjugated (4)

HRP Conjugated (4)

PE Conjugated (4)

Unconjugated (13)

Epitope

aa311-460 (8)

aa66-260 (8)

321-370 aa, Internal (1)

C-Terminus (1)

N-Terminus (1)

Tyr626 (1)

aa1-635 (1)

aa615-628 (1)

Publications

No (46)

Yes (1)

Sample Type

Cell Culture Supernatants (2)

Cell Lysates (2)

Plasma (2)

Serum (2)

Tissue Homogenates (1)

Tag

GST (1)

His (2)

His,C-terminus (1)

His-T7 (2)

Myc-DDK (Flag) (2)

Species

Human (5)

Mouse (1)

Rat (1)

Source

293T Cells (1)

Baculovirus (1)

E. coli (3)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Yeast (1)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (1)

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CD110 / MPL Antibody (aa615-628) LS-C26341

(4.0) Rating

(1) Publication(s)

Antibody:

CD110 / MPL Rabbit anti-Human Polyclonal (aa615-628) Antibody

Reactivity:

Mouse, Hamster, Human, Monkey

Applications:

IHC, IP, WB

Format:

Unconjugated

Price:

200 µg/$842

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CD110 / MPL Antibody (aa66-260) LS-C295475

Antibody:

CD110 / MPL Rabbit anti-Mouse Polyclonal (aa66-260) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206

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CD110 / MPL Antibody (aa66-260, HRP) LS-C709735

Antibody:

CD110 / MPL Rabbit anti-Mouse Polyclonal (aa66-260) (HRP) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$335; 200 µl/$389; 500 µl/$566; 1 ml/$685; 2 ml/$922; 5 ml/$1,557

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CD110 / MPL Antibody (aa66-260, Biotin) LS-C685938

Antibody:

CD110 / MPL Rabbit anti-Mouse Polyclonal (aa66-260) (Biotin) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$316; 200 µl/$361; 500 µl/$511; 1 ml/$587; 2 ml/$809; 5 ml/$1,317

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CD110 / MPL Antibody (aa66-260, FITC) LS-C692505

Antibody:

CD110 / MPL Rabbit anti-Mouse Polyclonal (aa66-260) (FITC) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$345; 200 µl/$402; 500 µl/$594; 1 ml/$737; 2 ml/$976; 5 ml/$1,676

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CD110 / MPL Antibody (aa66-260, APC) LS-C716879

Antibody:

CD110 / MPL Rabbit anti-Mouse Polyclonal (aa66-260) (APC) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

APC Conjugated

Price:

100 µl/$402; 200 µl/$484; 500 µl/$834; 1 ml/$991; 2 ml/$1,277; 5 ml/$2,395

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CD110 / MPL Antibody (aa66-260, PE) LS-C723795

Antibody:

CD110 / MPL Rabbit anti-Mouse Polyclonal (aa66-260) (PE) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

PE Conjugated

Price:

100 µl/$402; 200 µl/$484; 500 µl/$834; 1 ml/$991; 2 ml/$1,277; 5 ml/$2,395

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CD110 / MPL Antibody (aa66-260, APC, Cy7) LS-C732786

Antibody:

CD110 / MPL Rabbit anti-Mouse Polyclonal (aa66-260) (APC, Cy7) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

APC, Cy7 Conjugated

Price:

100 µl/$497; 200 µl/$632; 500 µl/$1,132; 1 ml/$1,369; 2 ml/$1,916; 5 ml/$3,592

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CD110 / MPL Antibody (aa66-260, Cy3) LS-C700712

Antibody:

CD110 / MPL Rabbit anti-Mouse Polyclonal (aa66-260) (Cy3) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Cy3 Conjugated

Price:

100 µl/$402; 200 µl/$484; 500 µl/$834; 1 ml/$991; 2 ml/$1,277; 5 ml/$2,395

• Unconjugated
• HRP
• Biotin
• FITC
• APC
• PE
• APC, Cy7
• More...
  • Cy3

• Unconjugated
• HRP
• Biotin
• More...
  • FITC
  • APC
  • PE
  • APC, Cy7
  • Cy3

Select

Rat CD110 / MPL Protein (Recombinant His,C-terminus) (Met1-Ala500) - LS-G138201

Source:

Baculovirus

Tag:

His,C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

55.1 kDa

Price:

50 µg/$483

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CD110 / MPL Antibody (PE) LS-C144232

Antibody:

CD110 / MPL Mouse anti-Human Monoclonal (PE) Antibody

Reactivity:

Human

Applications:

Flo

Format:

PE Conjugated

Price:

100 Tests/$824

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CD110 / MPL Antibody LS-C678675

Antibody:

CD110 / MPL Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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CD110 / MPL Antibody (Biotin) LS-C678678

Antibody:

CD110 / MPL Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• Biotin

• Unconjugated
• Biotin

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CD110 / MPL Antibody (clone 1D6B7) LS-C682570

Antibody:

CD110 / MPL Mouse anti-Human Monoclonal (1D6B7) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, WB

Format:

Unconjugated

Price:

100 µl/$459

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Mouse CD110 / MPL Protein (Recombinant His-T7) (aa66-260) - LS-G13847

Source:

E. coli

Tag:

His-T7

Molecular Weight:

25.2 kDa

Price:

10 µg/$290; 50 µg/$500; 100 µg/$797; 200 µg/$997; 1 mg/$2,139; 500 µg/$1,662; 5 mg/$3,487; 2 mg/$2,329

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Human CD110 / MPL (Sandwich ELISA) ELISA Kit - LS-F54984

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$834

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CD110 / MPL Antibody (clone 1H2) LS-C169168

Antibody:

CD110 / MPL Mouse anti-Human Monoclonal (1H2) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, WB

Format:

Unconjugated

Price:

100 µl/$459

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CD110 / MPL Antibody (clone 1H2) LS-C759670

Antibody:

CD110 / MPL Mouse anti-Human Monoclonal (1H2) Antibody

Reactivity:

Human

Applications:

Flo, WB

Format:

Unconjugated

Price:

100 µg/$503

Select

CD110 / MPL Antibody (C-Terminus) LS-C757520

Antibody:

CD110 / MPL Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$393

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CD110 / MPL Antibody (N-Terminus) LS-C757973

Antibody:

CD110 / MPL Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$393

Select

CD110 / MPL Antibody (321-370 aa, Internal) LS-C387224

Antibody:

CD110 / MPL Rabbit anti-Human Polyclonal (321-370 aa, Internal) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

CD110 / MPL Antibody (aa1-635) LS-C132438

Antibody:

CD110 / MPL Rabbit anti-Human Polyclonal (aa1-635) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µg/$749

Select

CD110 / MPL Antibody (Tyr626) LS-C777893

Antibody:

CD110 / MPL Rabbit anti-Human Polyclonal (Tyr626) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µg/$357

Select

CD110 / MPL Antibody LS-C777932

Antibody:

CD110 / MPL Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µg/$357

Select

CD110 / MPL Antibody (aa311-460) LS-C295474

Antibody:

CD110 / MPL Rabbit anti-Human Polyclonal (aa311-460) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$303; 200 µl/$343; 500 µl/$476; 1 ml/$543; 2 ml/$715; 5 ml/$1,182

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