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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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CD101 Antibody LS‑C44448
Note: This antibody replaces LS-C57758
Antibody
CD101 antibody LS-C44448 is an unconjugated mouse monoclonal antibody to human CD101. Validated for Flow, IHC and IP.
Catalog
Size
Price
LS-C44448-200
200 µg (1 mg/ml)
Unavailable

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Western blot analysis of CD101 expression in HEK293T (A); mouse brain (B); H9C2 (C) whole cell lysates.
Species: Human, Mouse, Rat
Applications: Western blot

Product Description

CD101 antibody LS-C44448 is an unconjugated mouse monoclonal antibody to human CD101. Validated for Flow, IHC and IP.
About CD101
Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3-induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Q93033 NM_004258 NP_004249.2

CD101 Antibody, CD101 antigen Antibody, CD101 molecule Antibody, Cell surface glycoprotein V7 Antibody, EWI101 Antibody, EWI-101 Antibody, IGSF2 Antibody, Leukocyte surface protein Antibody, V7 Antibody


Specifications

Target
Human CD101
Host
Mouse
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG1 Monoclonal
Conjugations
Unconjugated. Also available conjugated with FITC, RPE.
Purification
Protein G purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Frozen
  • Immunoprecipitation
  • Flow Cytometry (1:50 - 1:100)
  • (applications tested for the base form of this product only)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
CD101 antibody was raised against human thymic clone B12.
Specificity
Recognizes human CD101. CD101 is a 140kD homodimeric cell surface glycoprotein expressed primarily by monocytes, granulocytes, dendritic cells and activated T lymphocytes. Studies suggest that CD101 plays a major role in the activation of T cells by skin dendritic cells. Clone BB27 has been reported to inhibit allogeneic T-cell responses. Removal of sodium azide is recommended prior to use in functional assays. XXX recommend the use of EQU003 for this purpose.
Usage
Flow Cytometry: Use 10 ul of the suggested working dilution to label 10^6 cells in 100 ul. Method sheets are available on request.
Presentation
PBS, pH 7.4, 0.09% sodium azide.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Requested From: 
Date Requested: 6/17/2018

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