Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse (tested or 100% immunogen sequence identity)
Rat (at least 90% immunogen sequence identity)
Specificity and Use
CCR9 antibody was raised against synthetic peptide IPGMFDDFSYDSTASTDDYMNLNFSSFF corresponding to amino acids 10-37 of mouse CCR9. Percent identity by BLAST analysis: Mouse (100%); Rat (96%).
Peptide sequence is <50 % identical to other mouse chemokine receptors in this peptide region. The antibody recognizes mouse CCR9 and cross-reacts to human CCR9 due to 76 % homology within this peptide region.
10 mM KHPO4, 140 mM NaCl with 1 mg/ml BSA and 0.1% sodium azide
Long term: -70°C; Short term: -20°C; Avoid freeze-thaw cycles.
CCR9 is a member of the beta chemokine receptor family. It is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are key regulators of the thymocytes migration and maturation in normal and inflammation conditions. The specific ligand of this receptor is CCL25.