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Anti-CCR6 Antibody (aa18-46) IHC-plus™ LS-B2481

Note: This antibody replaces LS-C4360, LS-C4359

Ordering

Wt. Vol. Conc. Price
50 µg - 1 mg/ml $395
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular CCR6 Antibodies

Anti-CCR6 Antibody (Extracellular Domain) IHC-plus™ LS-A356
Rabbit Polyclonal to Human CCR6
Human
IHC - Paraffin
Unconjugated
Immunohistochemistry Image
Anti-CCR6 Antibody (C-Terminus) IHC-plus™ LS-A358
Rabbit Polyclonal to Human CCR6
Human, Monkey
IHC - Paraffin
Unconjugated
Immunohistochemistry Image
Anti-CCR6 Antibody (N-Terminus) LS-C121491
Rabbit Polyclonal (IgG) to Human CCR6
Human, Rat
IHC - Paraffin, Western blot
Unconjugated

100% Guaranteed 100% Guaranteed Publications Publications (1)
Goat Polyclonal (IgG) to Human CCR6
Human
IHC - Paraffin, ICC, Flow Cytometry, ELISA
Unconjugated

Details

Human CCR6
Goat
Human (tested or 100% immunogen sequence identity)
IgG Polyclonal
Unconjugated
Immunoaffinity purified
Unmodified

Applications

  • IHC - Paraffin (5 µg/ml)
  • ICC (1:300)
  • Flow Cytometry (1 - 3 µg/10E6 cells)
  • ELISA (1:75000)

Specificity and Use

CCR6 antibody was raised against synthetic peptide corresponding to aa 18-46 (Y18FVSVNTSYYSVDSEMLLCSLQEVRQFSR46) of human CCR6 (C-C chemokine receptor 6). Peptide sequence is <50% identical to other human chemokine receptors in this region. Percent identity by BLAST analysis: Human, Gorilla, Gibbon (100%); Monkey (86%).
aa18-46
Recognizes human CCR6. Peptide sequence is <50% identical to other human chemokine receptors in this region. Species cross-reactivity: mouse.
Immunohistochemistry: LS-B2481 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B2481 was determined to be 5 ug/ml. ELISA: 1:75000. Flow Cytometry: 50-100ul, 1-3 ul per 10^6 cells.

Packaging

PBS, 1 mg/ml BSA, 0.1% sodium azide.
Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
For research use only.

Publications (1)

1
Expression of the chemokine receptor CCR6 correlates with a favorable prognosis in patients with adenocarcinoma of the lung. Minamiya Y, Saito H, Takahashi N, Ito M, Toda H, Ono T, Konno H, Motoyama S, Ogawa J. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 2011 32:197-202. [PubMed:20872189]

About CCR6

P51684 NM_004367 NP_004358.2

CCR6 Antibody, C-c chemokine receptor 6 Antibody, CD196 antigen Antibody, BN-1 Antibody, C-C chemokine receptor type 6 Antibody, C-C CKR-6 Antibody, Chemokine c-c motif receptor 6 Antibody, CKRL3 Antibody, CMKBR6 Antibody, Chemokine (C-C) receptor 6 Antibody, Chemokine receptor-like 3 Antibody, Cc chemokine receptor 6 Antibody, CC-CKR-6 Antibody, CCR-6 Antibody, DCR2 Antibody, DRY6 Antibody, G protein-coupled receptor 29 Antibody, DRY-6 Antibody, G-protein coupled receptor 29 Antibody, GPR29 Antibody, GPRCY4 Antibody, Strl-22 Antibody, STRL22 Antibody, CD196 Antibody, CKR-L3 Antibody, GPR-CY4 Antibody, LARC receptor Antibody

CCR6 is a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha).

Immunohistochemistry

Immunohistochemistry
Anti-CCR6 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2481 concentration 5 ug/ml.
 

Requested From: United States
Date Requested: 12/5/2016

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