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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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CCR6 Antibody (aa18‑46) IHC‑plus™ LS‑B2481
Note: This antibody replaces LS-C4360, LS-C4359
CCR6 antibody LS-B2481 is an unconjugated goat polyclonal antibody to human CCR6. Validated for ELISA, Flow, ICC and IHC. Tested on 20 paraffin-embedded human tissues. Cited in 1 publication.
Catalog
Size
Price
LS-B2481-50
50 µg (1 mg/ml)
$425

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Product Description

CCR6 antibody LS-B2481 is an unconjugated goat polyclonal antibody to human CCR6. Validated for ELISA, Flow, ICC and IHC. Tested on 20 paraffin-embedded human tissues. Cited in 1 publication.
About CCR6
CCR6 is a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). P51684 NM_004367 NP_004358.2

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Specifications

Target
Human CCR6
Host
Goat
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (5 µg/ml)
  • ICC (1:300)
  • Flow Cytometry (1 - 3 µg/10E6 cells)
  • ELISA (1:75000)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
CCR6 antibody was raised against synthetic peptide corresponding to aa 18-46 (Y18FVSVNTSYYSVDSEMLLCSLQEVRQFSR46) of human CCR6 (C-C chemokine receptor 6). Peptide sequence is <50% identical to other human chemokine receptors in this region. Percent identity by BLAST analysis: Human, Gorilla, Gibbon (100%); Monkey (86%).
Epitope
aa18-46
Specificity
Recognizes human CCR6. Peptide sequence is <50% identical to other human chemokine receptors in this region. Species cross-reactivity: mouse.
Usage
Immunohistochemistry: LS-B2481 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B2481 was determined to be 5 ug/ml. ELISA: 1:75000. Flow Cytometry: 50-100ul, 1-3 ul per 10^6 cells.
Presentation
PBS, 1 mg/ml BSA, 0.1% Sodium Azide
Storage
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only.

Publications (1)

1
Expression of the chemokine receptor CCR6 correlates with a favorable prognosis in patients with adenocarcinoma of the lung. Minamiya Y, Saito H, Takahashi N, Ito M, Toda H, Ono T, Konno H, Motoyama S, Ogawa J. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 2011 32:197-202. [PubMed:20872189]

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Images

Immunohistochemistry

Anti-CCR6 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2481 concentration 5 ug/ml.
Anti-CCR6 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2481 concentration 5 ug/ml.

Immunohistochemistry

Anti-CCR6 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2481 concentration 5 ug/ml.
Anti-CCR6 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2481 concentration 5 ug/ml.

Immunohistochemistry

Anti-CCR6 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2481 concentration 5 ug/ml.
Anti-CCR6 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2481 concentration 5 ug/ml.

Immunohistochemistry

Anti-CCR6 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2481 concentration 5 ug/ml.
Anti-CCR6 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2481 concentration 5 ug/ml.

Requested From: United States
Date Requested: 9/25/2018

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