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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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CCR5 Antibody (phospho‑Ser349) LS‑C44710
Antibody
CCR5 antibody LS-C44710 is an unconjugated mouse monoclonal antibody to human CCR5. Validated for ELISA, Flow, IF and WB.
Catalog
Size
Price
LS-C44710-100
100 µg (1 mg/ml)
Unavailable

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Product Description

CCR5 antibody LS-C44710 is an unconjugated mouse monoclonal antibody to human CCR5. Validated for ELISA, Flow, IF and WB.
About CCR5
CCR5 is a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. P51681 NM_000579 NP_000570.1

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Specifications

Target
Human CCR5
Host
Mouse
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG1 Monoclonal
Conjugations
Unconjugated
Purification
Protein G purified
Modifications
Unmodified
Applications
  • Immunofluorescence (1:10 - 1:50)
  • Western blot
  • Flow Cytometry (1:10 - 1:50)
  • ELISA
Immunogen
CCR5 antibody was raised against synthetic phospho peptide corresponding to the C-Terminal region of human CD195 conjugated to BSA. ( pSer349 ).
Epitope
pSer349
Specificity
Specific for human CD195, a cell surface antigen of approximately 40kD, also known as CCR5. Has been demonstrated to exclusively recognize CD195 phosphorylated at Ser 349(1). Human CD195 is a member of the G protein coupled superfamily of receptors, which acts as a receptor for a number of chemokines including RANTES and also serves as a co-receptor for the entry of HIV into cells. It plays a key role in regulating the activation and migration of leukocytes. CD195 is expressed by a subset of T lymphocytes and by monocytes. Recent studies have shown that upon ligand stimulation, CD195 is rapidly phosphorylated within the C-terminal domain. Recognizes a band of approximately 40kD on Western blots of RBL-CCR5 cell lysates.
Usage
Western Blot: For the detection of phosphoproteins, serine phosphatase inhibitors such as 10 mM Sodium Fluoride should be added to the sample buffer. Milk or other casein-based blocking solutions are not recommended as casein is a phosphoprotein and its use can result in high background.
Presentation
PBS, pH 7.4, 0.09% sodium azide.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Requested From: 
Date Requested: 6/18/2018

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