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CCR5

chemokine (C-C motif) receptor 5 (gene/pseudogene)

CCR5 is a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene.

Gene Name: chemokine (C-C motif) receptor 5 (gene/pseudogene)
Family/Subfamily: GPCR , Chemokine
Synonyms: CCR5, C-C chemokine receptor 5, CD195 antigen, CD195, C-C CKR-5, Chemokine c-c motif receptor 5, Chemr13, CMKBR5, CKR5, Cc chemokine receptor 5, CCCKR5, CCR-5, Ccr5 receptor, Chemokine receptor CCR5, HIV-1 fusion coreceptor, IDDM22, C-C chemokine receptor type 5, CC-CKR-5, CKR-5
Target Sequences: NM_000579 NP_000570.1 P51681

Publications (4)

1
Identification of a linear peptide recognized by monoclonal antibody 2D7 capable of generating CCR5-specific antibodies with human immunodeficiency virus-neutralizing activity. Khurana S, Kennedy M, King LR, Golding H. Journal of virology. 2005 79:6791-800. (Flo) [PubMed:15890918] [PMC:PMC1112162]
2
Gp120 V3-dependent impairment of R5 HIV-1 infectivity due to virion-incorporated CCR5. Monde K, Maeda Y, Tanaka Y, Harada S, Yusa K. The Journal of biological chemistry. 2007 282:36923-32. [PubMed:17971448]
3
TLR2-dependent pathway of heterologous down-modulation for the CC chemokine receptors 1, 2, and 5 in human blood monocytes. Fox JM, Letellier E, Oliphant CJ, Signoret N. Blood. 2011 117:1851-60. [PubMed:21148810]
4
Chemokine receptor CXCR3 agonist prevents human T-cell migration in a humanized model of arthritic inflammation. O'Boyle G, Fox CR, Walden HR, Willet JD, Mavin ER, Hine DW, Palmer JM, Barker CE, Lamb CA, Ali S, Kirby JA. Proceedings of the National Academy of Sciences of the United States of America. 2012 109:4598-603. [PubMed:22392992] [PMC:PMC3311336]
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☰ Filters
Antibodies (106)
ELISA Kits (11)
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CCR5 (123)
Human (98)
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aa151-177 (7)
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CCR5 Antibody - Anti-CCR5 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
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CCR5 Mouse anti-Human Monoclonal (T21/8) Antibody
Human
ELISA, Flo, IHC, IHC-P, IP, WB
Unconjugated
50 µg/$460
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CCR5 Mouse anti-Human Monoclonal (aa1-22) (T21/8) Antibody
Human
ELISA, Flo, ICC, IP, WB
Unconjugated
0.1 mg/$302
CCR5 Antibody - Surface staining of CD195 in human peripheral blood with anti-CD195 (T21/8) PE.
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CCR5 Mouse anti-Human Monoclonal (aa1-22) (PE) (T21/8) Antibody
Human
ELISA, Flo, ICC, IP, WB
PE Conjugated
100 Tests/$365
CCR5 Antibody - Surface staining of CD195 in human peripheral blood with anti-CD195 (T21/8) APC.
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CCR5 Mouse anti-Human Monoclonal (aa1-22) (APC) (T21/8) Antibody
Human
ELISA, Flo, ICC, IP, WB
APC Conjugated
100 Tests/$365
CCR5 Antibody - IHC-P: CCR5 antibody testing of human rectal cancer tissue
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CCR5 Rabbit anti-Human Polyclonal (aa19-34) Antibody
Mouse, Human
WB
Unconjugated
100 µg/$575
CCR5 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
40.3 kDa
20 µg/$150
CCR5 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
CCR5 Antibody - Immunohistochemistry of CCR5 in human lymph node tissue with CCR5 antibody at 20 ug/ml.
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CCR5 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
0.1 mg/$460
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CCR5 Rabbit anti-Human Polyclonal (aa19-34) Antibody
Human, Monkey
IHC, IHC-P, WB
Unconjugated
100 µg/$723
CCR5 Antibody - Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE)
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CCR5 Rabbit anti-Human Polyclonal (aa292-341) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA
Unconjugated
100 µl/$515
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CCR5 Goat anti-Human Polyclonal Antibody
Human, Macaque
ELISA, ICC, IHC, WB
Unconjugated
100 µg/$556
CCR5 Antibody - Immunofluorescent analysis of HepG2 cells using CCR5 Antibody at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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CCR5 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IF, WB
Unconjugated
50 µg/$294; 100 µg/$360
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CCR5 Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat
IHC
Unconjugated
60 µl/$307; 120 µl/$367; 200 µl/$457
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CCR5 Rat anti-Human Monoclonal (FITC) (HEK/1/85a) Antibody
Human
Flo
FITC Conjugated
0.1 mg/$432
CCR5 Antibody - Fetal heart lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CCR5 Rabbit anti-Human Polyclonal (aa180-229) Antibody
Human
WB
Unconjugated
100 µl/$424
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CCR5 Mouse anti-Human Monoclonal (12D1) Antibody
Human
Flo, IF, IHC, IHC-Fr
Unconjugated
20 µg/$371; 100 µg/$574
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CCR5 Mouse anti-Human Monoclonal (Azide-free, BSA-free) (12D1) Antibody
Human
Flo, IF, IHC, IHC-Fr
Unconjugated, Azide-free, BSA-free
100 µg/$574
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CCR5 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µg/$564
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CCR5 Mouse anti-Human Polyclonal Antibody
Human
Flo, WB
Unconjugated
50 µg/$705
CCR5 Antibody - Western blot analysis of lysates from COS7 cells, using CCR5 Antibody. The lane on the right is blocked with the synthesized peptide.
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CCR5 Rabbit anti-Human Polyclonal (aa303-352) Antibody
Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
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CCR5 Rat anti-Mouse Monoclonal (11D98) Antibody
Mouse
WB
Unconjugated
100 µg/$896
CCR5 Antibody - CCR5 antibody Western blot. Lane 1: Mouse Lung Tissue Lysate. Lane 2: Mouse Intestine Tissue Lysate. Lane 3: Mouse Kidney Tissue Lysate.
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CCR5 Rabbit anti-Mouse Polyclonal (aa181-199) Antibody
Mouse
WB
Unconjugated
10 µg/$318; 100 µg/$470
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CCR5 Mouse anti-Human Monoclonal (6G11D1) Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
100 µl/$459
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CCR5 Rabbit anti-Human Polyclonal (N-Terminus) (Magnetic beads) Antibody
Rat, Human
IP
Magnetic beads Conjugated
100 µg/$399
CCR5 Antibody - Western blot analysis using CD195 mouse mAb against L-02 (1) cell lysate.
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CCR5 Mouse anti-Human Monoclonal (6H3D5) Antibody
Human
ELISA, Flo, WB
Unconjugated
100 µl/$459
Viewing 1-25 of 123 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).