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CCR5 Antibody (clone 12D1, Azide‑free) LS‑C390044

Catalog Number Size Price
LS-C390044-100 100 µg (1 mg/ml) $465 
Antibody

CCR5 Antibody (clone 12D1, Azide‑free) LS‑C390044

Antibody:
Mouse Monoclonal to Human CCR5
Application:
IHC, IHC-Fr, IF, Flo
Reactivity:
Human
Format:
Unconjugated, Azide-free
Other formats:
Price
Catalog Number
$465 
LS-C390044-100
Toll Free North America
866-819-4732

Overview

Antibody:
Mouse Monoclonal to Human CCR5
Application:
IHC, IHC-Fr, IF, Flo
Reactivity:
Human
Format:
Unconjugated, Azide-free
Other formats:

Specifications

Description
CCR5 antibody LS-C390044 is an unconjugated mouse monoclonal antibody to human CCR5. Validated for Flow, IF and IHC.
Target
Human CCR5
Host
Mouse
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG2a,k Monoclonal
Clone
12D1
Conjugations
Unconjugated
Purification
Protein G purified
Modifications
Azide-free. Also available Unmodified.
Applications
  • IHC
  • IHC - Frozen (0.5 - 1 µg/ml)
  • Immunofluorescence (0.5 - 1 µg/ml)
  • Flow Cytometry (0.5 - 1 µg/10E6 cells)
  • (applications tested for the base form of this product only)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Human native protein.
Specificity
Human CCR5
Usage
The applications listed have been tested for the unmodified form of this product. Other forms have not been tested. Reacts with the N-terminal extracellular domain of CD195. The CC chemokine receptor 5 (CCR5) is a member of the CC-chemokine receptor family, and has the characteristic structure of a 7 transmembrane G protein-coupled receptor (GPCR). CCR5 regulates trafficking and effector functions of memory/effector Th1 cells, macrophages, NK cells, and immature dendritic cells. CCR5 and its ligands play an important role in viral pathogenesis. CCR5 represents the co-receptor for macrophage (M) and dual (T cell and M)-tropic immunodeficiency viruses. Together with the CD4 binding receptor, CCR5 plays a critical role in HIV entry into the target cells. Moreover, the CCR5 ligands macrophage inflammatory protein (MIP)-1 alpha, MIP-1 beta and RANTES act as endogenous inhibitors of HIV infection, making both CCR5 and its chemokine ligands attractive therapeutic targets for HIV infection. Recent studies have also highlighted the role of CCR5 in a variety of other human diseases, ranging from infectious and inflammatory diseases to cancer. Optimal dilution of the CCR5 antibody should be determined by the researcher.
Presentation
Sterile Solution PBS
Storage
Store at -20°C or lower. Aliquot to avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About CCR5
P51681 NM_000579 NP_000570.1

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Requested From: United States
Date Requested: 9/16/2019