Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Immunofluorescence, Western blot, Flow Cytometry, ELISA
Human (tested or 100% immunogen sequence identity)
Protein G purified
Immunofluorescence (1:10 - 1:50)
Flow Cytometry (1:10 - 1:50)
Specificity and Use
CCR5 antibody was raised against synthetic phospho peptide corresponding to the C-Terminal region of human CD195 conjugated to BSA.
Recognizes human CD195 phosphorylated at Ser 349 at ~40kD.
Suitable for use in ELISA, Flow Cytometry, Immunofluorescence, and Western Blot. Flow Cytometry: 1:10-1:50; 10 ul labels 10^6 cells in 100ul. Immunofluorescence: 1:10-1:50.
PBS, pH 7.4, 0.09% sodium azide
May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C.
CCR5 is a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance.