Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone T21/8] (IgG1) to Human CCR5
ICC, Western blot, Immunoprecipitation, Flow Cytometry, ELISA
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [T21/8]
Protein A purified
Specificity and Use
CCR5 antibody was raised against cCR5 peptide (Met1-Lys22) KLH conjugate.
Monoclonal antibody T21/8 recognizes the N-terminus of CD195, an approximately 45 kD G-protein coupled receptor 1 family protein expressed on resting T cells, monocytes, macrophages, and immature dendritic cells.
Western Blotting: Application note - do not boil cell lysates prior to SDS-PAGE.
CCR5 is a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance.