Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse, Human (tested or 100% immunogen sequence identity)
IHC - Paraffin (5 µg/ml)
Western blot (1:500)
Specificity and Use
CCR3 antibody was raised against synthetic peptide TDEIKTVVESFETTPYEYEWAPPC corresponding to aa 5-28 of the N-terminal domain of mouse CCR3. Percent identity by BLAST analysis: Mouse (100%); Rat, Hamster (83%).
This antibody recognizes mouse CCR3 and the peptide sequence is <50 % identical to other chemokine receptors in this region.
10 mM KHPO4, 140 mM NaCl with 0.1% sodium azide and 1 mg/ml BSA
Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
CCR3 is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells.