Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Rat Monoclonal [clone 11n21] (IgG2a) to Human CCR3
Goat Polyclonal to Mouse CCR3
IHC, IHC - Paraffin, ICC, Western blot
Mouse, Human (tested or 100% immunogen sequence identity)
IHC - Paraffin (5 µg/ml)
Western blot (1:500)
Specificity and Use
CCR3 antibody was raised against synthetic peptide TDEIKTVVESFETTPYEYEWAPPC corresponding to aa 5-28 of the N-terminal domain of mouse CCR3. Percent identity by BLAST analysis: Mouse (100%); Rat, Hamster (83%).
This antibody recognizes mouse CCR3 and the peptide sequence is <50 % identical to other chemokine receptors in this region.
10 mM KHPO4, 140 mM NaCl with 0.1% sodium azide and 1 mg/ml BSA
Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
CCR3 is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells.