Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle. Koff A, Giordano A, Desai D, Yamashita K, Harper JW, Elledge S, Nishimoto T, Morgan DO, Franza BR, Roberts JM. Science (New York, N.Y.). 1992 257:1689-94.
Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family. Koff A, Cross F, Fisher A, Schumacher J, Leguellec K, Philippe M, Roberts JM. Cell. 1991 66:1217-28.
Functional analysis of pRb2/p130 interaction with cyclins. Claudio PP, De Luca A, Howard CM, Baldi A, Firpo EJ, Koff A, Paggi MG, Giordano A. Cancer research. 1996 56:2003-8.
CCNE1 Antibody, Cyclin E1 Antibody, CCNE Antibody, Cyclin Es Antibody, Cyclin Et Antibody, G1/S-specific cyclin-E1 Antibody, G1/s-specific cyclin e Antibody, Cyclin E Antibody
CCNE1 / Cyclin E1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition.