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CCND3 / Cyclin D3
cyclin D3
Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
| Gene Name: | cyclin D3 |
| Synonyms: | CCND3, D3-type cyclin, G1/S-specific cyclin D3, G1/S-specific cyclin-D3, Cyclin D3 |
| Target Sequences: | NM_001760 NP_001751.1 P30281 |
☰ Filters
Products
Antibodies
(82)
ELISA Kits
(13)
Proteins
(7)
Type
Cell-Based
(1)
Cell-Based Phosphorylation
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(1)
Over-Expression Lysate
(2)
Primary
(82)
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(5)
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(6)
Sandwich CLIA
(1)
Target
CCND3 / Cyclin D3
(102)
Reactivity
Human
(84)
Mouse
(48)
Rat
(43)
Bat
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Dog
(3)
Gibbon
(3)
Horse
(3)
Monkey
(13)
Pig
(3)
Sheep
(3)
Application
IHC
(43)
IHC-Fr
(1)
IHC-P
(12)
WB
(67)
Flo
(8)
DB
(14)
ELISA
(22)
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(2)
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(8)
IP
(9)
Neut
(5)
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(4)
Host
rabbit
(70)
mouse
(12)
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DevKit DuoPlus
(1)
PathPlus Cancer
(1)
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IgG
(39)
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(10)
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(2)
Clonality
monoclonal mc
(12)
polyclonal pc
(70)
Clone
DCS-22
(1)
TS106
(1)
Format
12 x 8-Well Microstrips
(1)
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(3)
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(8)
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(1)
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(1)
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(1)
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(6)
Atto 390 Conjugated
(1)
Atto 488 Conjugated
(1)
Atto 594 Conjugated
(1)
Azide-free
(2)
Biotin Conjugated
(7)
Cy3 Conjugated
(1)
Cy7 Conjugated
(1)
FITC Conjugated
(7)
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(6)
PE Conjugated
(5)
PerCP Conjugated
(1)
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(1)
Unconjugated
(43)
Epitope
pThr283
(12)
aa1-292
(10)
C-Terminus
(7)
pSer264
(7)
220-300 aa
(2)
Gly277
(2)
aa136-292
(1)
aa241-260
(1)
aa243-292
(1)
aa252-281
(1)
aa33-66
(1)
p283
(1)
Publications
No
(102)
Sample Type
Adherent Cell Cultures
(2)
Cell Culture Supernatants
(3)
Cell Lysates
(2)
Plasma
(5)
Serum
(5)
Tissue Homogenates
(4)
Tag
GST
(1)
GST, N-terminus
(2)
GST, N-terminus + His, C-terminus
(1)
His, N-Terminal
(1)
Myc-DDK (Flag)
(2)
Species
Human
(6)
Source
293T Cells
(1)
E. coli
(3)
HEK 293 Cells
(1)
Wheat Germ Extract
(2)
Purification
Purified
(2)
Sandwich
96-Well Strip Plate
Human
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$783
E. coli
His, N-Terminal
36.3 kDa
50 µg/$432; 10 µg/$279; 200 µg/$862; 100 µg/$690; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148
Cancer
CCND3 / Cyclin D3 Rabbit anti-Human Polyclonal (aa252-281) Antibody
Mouse, Human
IHC-P, WB
Unconjugated
200 µl/$460
Cell-Based
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$618
CCND3 / Cyclin D3 Mouse anti-Human Monoclonal (aa1-292) (TS106) Antibody
Human
IHC, WB
Unconjugated
100 µg/$884
CCND3 / Cyclin D3 Rabbit anti-Human Polyclonal Antibody
Human
IP, WB
Unconjugated
100 µl/$412
CCND3 / Cyclin D3 Rabbit anti-Mouse Polyclonal (C-Terminus) Antibody
Mouse
ELISA, Flo, IHC, IP, WB
Unconjugated
100 µg/$567
CCND3 / Cyclin D3 Rabbit anti-Mouse Polyclonal (C-Terminus) Antibody
Mouse
ELISA, Flo, IHC, IP, WB
Unconjugated
25 µl/$304
CCND3 / Cyclin D3 Rabbit anti-Human Polyclonal (pThr283) Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CCND3 / Cyclin D3 Rabbit anti-Human Polyclonal (aa1-292) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$294; 100 µl/$360
CCND3 / Cyclin D3 Mouse anti-Human Monoclonal (HRP) Antibody
Mouse, Rat, Human, Monkey
Flo, IF, IHC, IP, Neut, WB
HRP Conjugated
100 µl/$1,071
CCND3 / Cyclin D3 Mouse anti-Human Monoclonal (Biotin) Antibody
Mouse, Rat, Human, Monkey
Flo, IF, IHC, IP, Neut, WB
Biotin Conjugated
100 µl/$1,071
CCND3 / Cyclin D3 Mouse anti-Human Monoclonal (FITC) Antibody
Mouse, Rat, Human, Monkey
Flo, IF, IHC, IP, Neut, WB
FITC Conjugated
100 µl/$1,071
CCND3 / Cyclin D3 Mouse anti-Human Monoclonal (PE) Antibody
Mouse, Rat, Human, Monkey
Flo, IF, IHC, IP, Neut, WB
PE Conjugated
100 µl/$1,071
CCND3 / Cyclin D3 Mouse anti-Human Monoclonal (APC) Antibody
Mouse, Rat, Human, Monkey
Flo, IF, IHC, IP, Neut, WB
APC Conjugated
100 µl/$1,071
CCND3 / Cyclin D3 Mouse anti-Human Monoclonal Antibody
Mouse, Human, Monkey
Flo, IHC, IHC-Fr, IHC-P, WB
Unconjugated
50 µg/$780
CCND3 / Cyclin D3 Mouse anti-Human Monoclonal Antibody
Mouse, Rat, Human
ICC, IHC, IHC-P, IP, WB
Unconjugated
100 µg/$564
CCND3 / Cyclin D3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human, Monkey
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
CCND3 / Cyclin D3 Rabbit anti-Human Polyclonal (pThr283) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
CCND3 / Cyclin D3 Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF, WB
Unconjugated
100 µl/$412
CCND3 / Cyclin D3 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$331
CCND3 / Cyclin D3 Rabbit anti-Human Polyclonal (220-300 aa) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CCND3 / Cyclin D3 Rabbit anti-Human Polyclonal (p283) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
CCND3 / Cyclin D3 Mouse anti-Human Monoclonal (aa241-260) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$665
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of 102
product results
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