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CCND1 / Cyclin D1
cyclin D1
Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner.
| Gene Name: | cyclin D1 |
| Synonyms: | CCND1, B-cell lymphoma 1 protein, BCL-1 oncogene, B-cell CLL/lymphoma 1, BCL-1, Cyclin D1, G1/S-specific cyclin-D1, U21B31, PRAD1, BCL1, D11S287E, PRAD1 oncogene |
| Target Sequences: | NM_053056 NP_444284.1 P24385 |
Publications (4)
1
Unraveling the therapeutic potential of GANT61/Dactolisib combination as a novel prostate cancer modality. Mohamed Youssef, Nermine Moussa, Maged W Helmy, Medhat Haroun. Medical oncology (Northwood, London, England). 2022 July;39:143. [Full Text Article]
[PubMed:35834137]
[PMC:PMC9283339]
2
GANT61/BI-847325 combination: a new hope in lung cancer treatment. Abdel Halim M El-Kishky, Nermine Moussa, Maged W Helmy, Medhat Haroun. Medical oncology (Northwood, London, England). 2022 July;39:144. [Full Text Article]
[PubMed:35834029]
[PMC:PMC9283175]
3
Quercetin potentiates 5-fluorouracil effects in human colon cancer cells through targeting the Wnt/ß-catenin signalling pathway: the role of miR-27a. Ghada T Terana, Mohamed M Abd-Alhaseeb, Gamal A Omran, Tarek M Okda. Contemporary oncology (Poznan, Poland). 2022 November;26:229-238. [Full Text Article]
[PubMed:36381675]
[PMC:PMC9641630]
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CCND1 / Cyclin D1 Rabbit anti-Human Polyclonal (aa68-97) Antibody
Mouse, Human
IF, IHC, IHC-P, WB
Unconjugated
200 µl/$460
CCND1 / Cyclin D1 Mouse anti-Human Monoclonal (CD1.1) Antibody
Rat, Human
ELISA, Flo, ICC, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
50 µg/$460
Sandwich
96-Well Strip Plate
Mouse
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
E. coli
6His, N-terminus
37.8 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Cancer Pathology
Cancer
CCND1 / Cyclin D1 Rabbit anti-Human Polyclonal (aa250-300) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
100 µg/$460
Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates
1 Plate/$764
CCND1 / Cyclin D1 Mouse anti-Human Monoclonal (DCS-6) Antibody
Mouse, Rat, Human, Monkey
Flo, IF, IHC, IHC-P, WB
Unconjugated
20 µg/$371; 100 µg/$574
CCND1 / Cyclin D1 Mouse anti-Human Monoclonal (3B6G3) Antibody
Human
ELISA, Flo, IHC-P, WB
Unconjugated
100 µl/$485
CCND1 / Cyclin D1 Rabbit anti-Human Polyclonal (220-300 aa) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CCND1 / Cyclin D1 Mouse anti-Human Monoclonal (SPM587) Antibody
Mouse, Rat, Human, Monkey
Flo, IF, IHC, IHC-P, WB
Unconjugated
20 µg/$371; 100 µg/$574
CCND1 / Cyclin D1 Mouse anti-Human Monoclonal (Azide-free, BSA-free) (SPM587) Antibody
Mouse, Rat, Human, Monkey
Flo, IF, IHC, IHC-P, WB
Unconjugated, Azide-free, BSA-free
100 µg/$574
CCND1 / Cyclin D1 Mouse anti-Human Monoclonal Antibody
Mouse, Rat, Human, Monkey
ELISA, Flo, IF, IHC, IHC-P, WB
Unconjugated
20 µg/$468; 100 µg/$688
CCND1 / Cyclin D1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
WB
Unconjugated
10 µg/$318; 100 µg/$470
CCND1 / Cyclin D1 Rabbit anti-Human Polyclonal (pThr286) Antibody
Mouse, Rat, Human
ICC, IF, IHC, WB
Unconjugated
50 µg/$305; 100 µg/$357
CCND1 / Cyclin D1 Rabbit anti-Chicken Polyclonal (aa1-292) Antibody
Chicken
WB
Unconjugated
100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206
CCND1 / Cyclin D1 Rabbit anti-Mouse Polyclonal (C-Terminus) Antibody
Mouse, Human
Compet, ELISA, ICC, IHC, IP, WB
Unconjugated
100 µl/$424
CCND1 / Cyclin D1 Mouse anti-Human Monoclonal Antibody
Mouse, Rat, Human
ICC, IHC, IHC-Fr, IHC-P, WB
Unconjugated
100 µg/$564
CCND1 / Cyclin D1 Mouse anti-Human Monoclonal (DCS-6) Antibody
Mouse, Rat, Non-Human Primates, Human
Flo, Func, ICC, IHC-Fr, IHC-P, IP, WB
Unconjugated
0.1 mg/$302
Sandwich
96-Well Microplate
Human
0.31 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
CCND1 / Cyclin D1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100 µl/$332
CCND1 / Cyclin D1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IP, WB
Unconjugated
100 µl/$567
CCND1 / Cyclin D1 Mouse anti-Human Monoclonal (CCND1/809) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
20 µg/$371; 100 µg/$574
CCND1 / Cyclin D1 Mouse anti-Human Monoclonal (Azide-free, BSA-free) (CCND1/809) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated, Azide-free, BSA-free
100 µg/$574
CCND1 / Cyclin D1 Mouse anti-Human Monoclonal (Ready-to-Use) (CCND1/809) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated, Ready-to-Use
7 ml/$574
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of 264
product results
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