CCM1 / KRIT1

KRIT1, ankyrin repeat containing

Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity (By similarity). Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Promotes AKT phosphorylation in a NOTCH-dependent and independent manner, and inhibits ERK1/2 phosphorylation indirectly through activation of the DELTA-NOTCH cascade. Acts in concert with CDH5 to establish and maintain correct endothelial cell polarity and vascular lumen and these effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction, and cell junction stabilization. Plays a role in integrin signaling via its interaction with ITGB1BP1; this prevents the interaction between ITGB1 and ITGB1BP1. Microtubule-associated protein that binds to phosphatidylinositol 4,5-bisphosphate (PIP2)-containing membranes in a GTP-bound RAP1-dependent manner. Plays an important role in the maintenance of the intracellular reactive oxygen species (ROS) homeostasis to prevent oxidative cellular damage. Regulates the homeostasis of intracellular ROS through an antioxidant pathway involving FOXO1 and SOD2. Facilitates the down-regulation of cyclin-D1 (CCND1) levels required for cell transition from proliferative growth to quiescence by preventing the accumulation of intracellular ROS through the modulation of FOXO1 and SOD2 levels.

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Products

Antibodies (15)

Proteins (2)

Type

Primary (15)

Recombinant (2)

Target

CCM1 / KRIT1 (17)

Reactivity

Human (15)

Mouse (3)

Rat (3)

Application

IHC (1)

IHC-P (1)

WB (9)

ELISA (11)

IF (2)

Host

rabbit (14)

mouse (1)

Isotype

IgG (13)

IgG2a,l (1)

Clonality

monoclonal mc (1)

polyclonal pc (14)

Clone

2C7 (1)

Format

APC Conjugated (1)

Azide-free (1)

Biotin Conjugated (2)

FITC Conjugated (2)

HRP Conjugated (2)

PE Conjugated (1)

Unconjugated (7)

Epitope

aa6-34 (6)

Publications

No (17)

Tag

GST (1)

GST, N-terminus (1)

Species

Human (2)

Source

Wheat Germ Extract (2)

Purification

Purified (1)

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CCM1 / KRIT1 Antibody LS-C346127

Antibody:

CCM1 / KRIT1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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CCM1 / KRIT1 Antibody LS-C680745

Antibody:

CCM1 / KRIT1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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CCM1 / KRIT1 Antibody (HRP) LS-C680750

Antibody:

CCM1 / KRIT1 Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

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CCM1 / KRIT1 Antibody (Biotin) LS-C680748

Antibody:

CCM1 / KRIT1 Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

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CCM1 / KRIT1 Antibody (FITC) LS-C680747

Antibody:

CCM1 / KRIT1 Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

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CCM1 / KRIT1 Antibody (aa6-34) LS-C322549

Antibody:

CCM1 / KRIT1 Rabbit anti-Human Polyclonal (aa6-34) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

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CCM1 / KRIT1 Antibody (aa6-34, Biotin) LS-C236926

Antibody:

CCM1 / KRIT1 Rabbit anti-Human Polyclonal (aa6-34) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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CCM1 / KRIT1 Antibody (aa6-34, FITC) LS-C236927

Antibody:

CCM1 / KRIT1 Rabbit anti-Human Polyclonal (aa6-34) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

200 µl/$952

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CCM1 / KRIT1 Antibody (aa6-34, Azide-free, HRP) LS-C248668

Antibody:

CCM1 / KRIT1 Rabbit anti-Human Polyclonal (aa6-34) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

Select

CCM1 / KRIT1 Antibody (aa6-34, APC) LS-C236928

Antibody:

CCM1 / KRIT1 Rabbit anti-Human Polyclonal (aa6-34) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

CCM1 / KRIT1 Antibody (aa6-34, PE) LS-C236929

Antibody:

CCM1 / KRIT1 Rabbit anti-Human Polyclonal (aa6-34) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• HRP, Azide-free
• APC
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • HRP, Azide-free
  • APC
  • PE

Select

CCM1 / KRIT1 Antibody LS-C834383

Antibody:

CCM1 / KRIT1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

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CCM1 / KRIT1 Antibody (clone 2C7) LS-C196831

Antibody:

CCM1 / KRIT1 Mouse anti-Human Monoclonal (2C7) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Unconjugated

Price:

100 µg/$423

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CCM1 / KRIT1 Antibody LS-C662359

Antibody:

CCM1 / KRIT1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

Select

CCM1 / KRIT1 Antibody LS-C781875

Antibody:

CCM1 / KRIT1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µg/$575

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Human CCM1 / KRIT1 Protein (Recombinant GST, N-terminus) (aa637-736) - LS-G58014

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

Select

Human CCM1 / KRIT1 Protein (Recombinant GST) (Full Length) - LS-G27771

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

110.7 kDa

Price:

2 µg/$439

Viewing 1-17 of 17 product results

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