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Anti-CCL8 / MCP2 Antibody (Biotin) LS-C187696

Catalog Size Price
LS-C187696-50 50 µg (0.1 mg/ml) Unavailable

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100% Guaranteed
Rabbit Polyclonal (IgG) to Mouse CCL8 / MCP2
Mouse
Western blot, ELISA
Biotin Conjugated

Details

Mouse CCL8 / MCP2
Rabbit
Mouse (tested or 100% immunogen sequence identity)
IgG Polyclonal
Biotin
Affinity purified
Unmodified

Applications

  • Western blot (0.1 - 0.2 µg/ml)
  • ELISA (0.25 - 1 µg/ml)

Specificity and Use

CCL8 / MCP2 antibody was raised against recombinant mouse MCP-2.
Recognizes mouse MCP-2 (Monocyte Chemoattractant Protein 2), otherwise known as CCL8, a CC chemokine originally isolated from the human osteosarcoma cell line MG-63, which is expressed at highest levels in peripheral blood cells and the small intestine. MCP-2 acts as a chemoattractant for monocytes, lymphocytes, eosinophils and basophils, and signals through binding to the common MCP receptor, chemokine (C-C motif) receptor 2 (CCR2), and also CCR1 and CCR3. Proteolytic cleavage of MCP-2 into the NH2-terminally truncated form, MCP-2 (6-76), results in the loss of chemotactic activity, forming a functional CC chemokine inhibitor, which may be important during inflammatory responses.
The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.

Packaging

PBS
500 µl Sterile PBS
Prior to reconstitution, +4°C. Following reconstitution store at -20°C. Avoid freeze-thaw cycles.
For research use only.

About CCL8 / MCP2

P80075 NM_005623 NP_005614.2

CCL8 Antibody, C-C motif chemokine 8 Antibody, HC14 Antibody, MCP2 Antibody, Monocyte chemotactic protein 2 Antibody, Scya10 Antibody, SCYA8 Antibody, Small-inducible cytokine A8 Antibody, MCP-2 Antibody, Chemokine (C-C motif) ligand 8 Antibody

This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues.

Requested From: 
Date Requested: 6/26/2017

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