(tested or 100% immunogen sequence identity)
CCL8 / MCP2 antibody was raised against recombinant mouse MCP-2.
Recognizes mouse MCP-2 (Monocyte Chemoattractant Protein 2), otherwise known as CCL8, a CC chemokine originally isolated from the human osteosarcoma cell line MG-63, which is expressed at highest levels in peripheral blood cells and the small intestine. MCP-2 acts as a chemoattractant for monocytes, lymphocytes, eosinophils and basophils, and signals through binding to the common MCP receptor, chemokine (C-C motif) receptor 2 (CCR2), and also CCR1 and CCR3. Proteolytic cleavage of MCP-2 into the NH2-terminally truncated form, MCP-2 (6-76), results in the loss of chemotactic activity, forming a functional CC chemokine inhibitor, which may be important during inflammatory responses.
The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.
Prior to reconstitution, 4°C. Following reconstitution store at -20°C. Avoid freeze-thaw cycles.
This antibody carries the LSBio 100% Guarantee.