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CCL5 / RANTES

chemokine (C-C motif) ligand 5

Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils (PubMed:16791620, PubMed:1380064, PubMed:8525373, PubMed:9516414, PubMed:15923218). May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilization through its activation. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells (PubMed:23979485).

Gene Name: chemokine (C-C motif) ligand 5
Family/Subfamily: Intercrine , not assigned-Intercrine
Synonyms: CCL5, Chemokine (C-C motif) ligand 5, D17S136E, EoCP, T-cell specific protein p288, SCYA5, SISd, T cell-specific protein P228, Beta-chemokine RANTES, C-C motif chemokine 5, RANTES, SIS-delta, Small-inducible cytokine A5, T-cell-specific protein RANTES, TCP228
Target Sequences: NM_002985 NP_002976.2 P13501

Publications (2)

1
RANKL-Expressing Ectopic Extramammary Paget's Disease on the Lower Abdomen. Hagiwara-Takita A, Fujimura T, Kakizaki A, Aiba S. Case reports in dermatology. 2016 8:130-5. (IF; Human) [Full Text Article] [PubMed:27462221] [PMC:PMC4943311]
2
Glial- and Neuronal-Specific Expression of CCL5 mRNA in the Rat Brain. Lanfranco MF, Mocchetti I, Burns MP, Villapol S. Frontiers in neuroanatomy. 2018 January;11:137. (Mouse) [Full Text Article] [PubMed:29375328] [PMC:PMC5770405] Related Antibodies: LS-C104689.

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CCL5 / RANTES Antibody - Western Blot (non-reducing) of CCL5 / RANTES antibody. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CCL5 / RANTES Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA, WB
Unconjugated
50 µg/$356; 100 µg/$396
CCL5 / RANTES Antibody - Anti-CCL5 / RANTES antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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CCL5 / RANTES Mouse anti-Human Monoclonal (8.PP.11) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$495
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CCL5 / RANTES Mouse anti-Human Monoclonal (APC) Antibody
Human
ELISA, IHC, Neut, WB
APC Conjugated
100 µl/$763
CCL5 / RANTES Antibody - Western Blot (non-reducing) of CCL5 / RANTES antibody. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CCL5 / RANTES Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$356; 100 µg/$396
CCL5 / RANTES Antibody - Western Blot (non-reducing) of CCL5 / RANTES antibody. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CCL5 / RANTES Rabbit anti-Rat Polyclonal Antibody
Rat
ELISA, WB
Unconjugated
50 µg/$356; 100 µg/$396
CCL5 / RANTES Antibody - IHC analysis of RANTES antibody in paraffin-embedded human lung carcinoma tissue
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CCL5 / RANTES Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CCL5 / RANTES ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
CCL5 / RANTES ELISA Kit
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Sandwich
96-Well Microplate
Human
2.743 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$588
CCL5 / RANTES Antibody - 1:100 staining human Melanoma tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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CCL5 / RANTES Rabbit anti-Human Polyclonal Antibody
Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CCL5 / RANTES ELISA Kit
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Sandwich
96-Well Strip Plate
Pig
3.12 - 200 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$889
CCL5 / RANTES ELISA Kit
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Sandwich
96-Well Microplate
Mouse
0.819 - 200 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$470
CCL5 / RANTES ELISA Kit
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Sandwich
96-Well Strip Plate
Dog
39 - 2500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$929
CCL5 / RANTES ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
78.13 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$488
CCL5 / RANTES Antibody - Anti-Human RANTES (CCL5) Western Blot Unreduced
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CCL5 / RANTES Mouse anti-Human Monoclonal Antibody
Human
ELISA, WB
Unconjugated
500 µg/$326
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CCL5 / RANTES Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µg/$305; 100 µg/$357
CCL5 / RANTES Antibody - NIH 3T3 Cell Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CCL5 / RANTES Rabbit anti-Mouse Polyclonal (aa26-75) (FITC) Antibody
Mouse
WB
FITC Conjugated
100 µl/$442
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CCL5 / RANTES Rabbit anti-Rat Polyclonal Antibody
Mouse, Rat
WB
Unconjugated
250 µg/$508
CCL5 / RANTES ELISA Kit
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Sandwich
96-Well Strip Plate
39 - 2500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
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E. coli
His
9.3 kDa
10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
CCL5 / RANTES ELISA Kit
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Development Kit
200 Wells
Mouse
16 - 2000 pg/ml
Colorimetric - 405nm (ABTS)
1 Test/$180
CCL5 / RANTES ELISA Kit
Select
Development Kit
200 Wells
Rat
16 - 2000 pg/ml
Colorimetric - 405nm (ABTS)
1 Test/$180
CCL5 / RANTES ELISA Kit
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Sandwich CLIA
96-Well Strip Plate
Mouse
13.72 - 10000 pg/ml
Chemiluminescent
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$990
CCL5 / RANTES Protein - SDS-PAGE under reducing conditions and visualized by Coomassie blue staining
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E. coli
6His, N-terminus
10 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365
CCL5 / RANTES ELISA Kit
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Sandwich
96-Well Strip Plate
Guinea pig
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$854
CCL5 / RANTES Protein - Purified recombinant protein CCL5 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
7.8 kDa
20 µg/$1,107
Viewing 1-25 of 222 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).