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Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors. Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress.
Gene Name: | cell cycle and apoptosis regulator 2 |
Synonyms: | CCAR2, DBC.1, DBIRD complex subunit KIAA1967, Deleted in breast cancer 1, DBC-1, KIAA1967, NET35, p30 DBC protein, p30 DBC, p30DBC |
Target Sequences: | NM_021174 NP_066997.3 Q8N163 |
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