Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse, Human (tested or 100% immunogen sequence identity)
Tissue culture supernatant
IHC - Frozen
Specificity and Use
CBX1 / HP1 Beta antibody was raised against 71 amino acid GST fusion protein corresponding to the c-terminal region of M31.
Recognizes the M31 molecule in mouse and the homologous HP1 HS beta molecule in man. Reported for use in Western Blot and recognizes a 26kD protein in mouse and human nuclear extracts. Species cross-reactivity: Mouse, human.
Suitable for use in ELISA, Western Blot, Immunohistochemistry. Immunohistochemistry (frozen): 1:50.
Tissue Culture Supernatant. Supplied as a liquid, 0.1% sodium azide.
Long term: Add glycerol (40-50%) -20°C; Short term: +4°C
CBX1 / HP1 Beta is a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins.