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CBFA2T3 is a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16;21)(q24;q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. This gene is also a putative breast tumor suppressor. Alternative splicing results in transcript variants.
Gene Name: | core-binding factor, runt domain, alpha subunit 2; translocated to, 3 |
Synonyms: | CBFA2T3, ETO2, MTG8-related gene 2, MTGR2, MTG16, MTG8-related protein 2, Protein CBFA2T3, Translocated to, 3, ZMYND4, HMTG16 |
Target Sequences: | NM_005187 NP_005178.4 O75081 |
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