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CBFA2T2 / MTGR1

core-binding factor, runt domain, alpha subunit 2; translocated to, 2

In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.

Gene Name: core-binding factor, runt domain, alpha subunit 2; translocated to, 2
Synonyms: CBFA2T2, Brain mtgr1 mrna, partial 5', EHT, ETO homolog on chromosome 20, MTGR1, p85, MTG8-like protein, MTG8-related protein 1, Translocated to, 2, Protein CBFA2T2, ZMYND3
Target Sequences: NM_005093 NP_005084.1 O43439

☰ Filters
Antibodies (41)
Proteins (5)
Over-Expression Lysate (2)
Primary (41)
Recombinant (3)
CBFA2T2 / MTGR1 (46)
Human (34)
Mouse (15)
Rat (11)
Bovine (3)
Chicken (3)
Chimpanzee (3)
Dog (3)
Gibbon (9)
Guinea pig (3)
Hamster (3)
Horse (3)
Monkey (12)
Pig (3)
IHC (10)
IHC-P (8)
WB (40)
Flo (1)
DB (1)
ELISA (12)
ICC (3)
IF (5)
IP (3)
Peptide-ELISA (1)
rabbit (34)
mouse (5)
rat (1)
sheep (1)
Product Group
IHCPlus (2)
IgG (29)
IgG1 (2)
IgG2b,k (1)
IgG2c (2)
monoclonal mc (5)
polyclonal pc (36)
2C10 (1)
CBF5I134 (1)
KT42 (1)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (5)
FITC Conjugated (5)
HRP Conjugated (5)
PE Conjugated (1)
Unconjugated (24)
aa1-29 (7)
C-Terminus (4)
N-Terminus (4)
aa357-406 (4)
aa361-410 (4)
aa401-604 (1)
aa554-604 (1)
No (46)
GST (1)
GST, N-terminus (1)
Myc-DDK (Flag) (3)
Human (4)
293T Cells (1)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Purified (1)
CBFA2T2 / MTGR1 Antibody - Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
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CBFA2T2 / MTGR1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
CBFA2T2 / MTGR1 Antibody - Immunoperoxidase of monoclonal antibody to CBFA2T2 on formalin-fixed paraffin-embedded human salivary gland. [antibody concentration 3 ug/ml]
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CBFA2T2 / MTGR1 Mouse anti-Human Monoclonal (2C10) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
100 µg/$423
CBFA2T2 / MTGR1 Antibody - Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CBFA2T2 / MTGR1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
CBFA2T2 / MTGR1 Antibody - Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CBFA2T2 / MTGR1 Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody
Chicken, Bovine, Dog, Guinea pig, Pig, Horse, Gibbon, Human, Monkey
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
CBFA2T2 / MTGR1 Antibody - Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CBFA2T2 / MTGR1 Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Chicken, Bovine, Dog, Guinea pig, Pig, Horse, Gibbon, Human, Monkey
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
CBFA2T2 / MTGR1 Antibody - Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CBFA2T2 / MTGR1 Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody
Chicken, Bovine, Dog, Guinea pig, Pig, Horse, Gibbon, Human, Monkey
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
CBFA2T2 / MTGR1 Antibody - Immunohistochemistry of paraffin-embedded human testis tissue at dilution 1:100
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CBFA2T2 / MTGR1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$294; 100 µl/$360
CBFA2T2 / MTGR1 Antibody - Immunofluorescent staining using CBFA2T2 antibody. Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were stained with anti-CBFA2T2 antibody.
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CBFA2T2 / MTGR1 Mouse anti-Human Monoclonal (CBF5I134) Antibody
Human
DB, Flo, ICC, WB
Unconjugated
100 µg/$965
CBFA2T2 / MTGR1 Antibody - Immunohistochemistry of paraffin-embedded human testis tissue at dilution 1:100
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CBFA2T2 / MTGR1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$294; 100 µl/$360
CBFA2T2 / MTGR1 Antibody - Immunofluorescent analysis of MTGR1 staining in U2OS cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 deg C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark.
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CBFA2T2 / MTGR1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ICC, IF, WB
Unconjugated
50 µl/$286; 100 µl/$321; 200 µl/$386
Select
CBFA2T2 / MTGR1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$341
Select
CBFA2T2 / MTGR1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
CBFA2T2 / MTGR1 Antibody - Immunohistochemistry of paraffin-embedded Human breast cancer tissue  using CBFA2T2 Polyclonal Antibody at dilution of 1:60(×200)
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CBFA2T2 / MTGR1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
CBFA2T2 / MTGR1 Antibody - Fluorescent image of HeLa cell stained with CBFA2T2 Antibody. HeLa cells were fixed with 4% PFA (20 min), permeabilized with Triton X-100 (0.1%, 10 min), then incubated with CBFA2T2 primary antibody (1:25, 1 h at 37°C). For secondary antibody, Alexa Fluor 488 conjugated donkey anti-rabbit antibody (green) was used (1:400, 50 min at 37°C). Cytoplasmic actin was counterstained with Alexa Fluor 555 (red) conjugated Phalloidin (7units/ml, 1 h at 37°C). CBFA2T2 immunoreactivity is localized to Nucleus significantly.
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CBFA2T2 / MTGR1 Rabbit anti-Human Polyclonal (aa1-29) Antibody
Human
IF, WB
Unconjugated
400 µl/$393
Select
CBFA2T2 / MTGR1 Rat anti-Mouse Monoclonal (KT42) Antibody
Mouse
IP, WB
Unconjugated
100 µg/$454
CBFA2T2 / MTGR1 Antibody - Immunofluorescence of paraformaldehyde-fixed HeLa using CBFA2T2 antibody at 1:200 dilution.
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CBFA2T2 / MTGR1 Rabbit anti-Human Polyclonal (aa401-604) Antibody
Human
ICC, WB
Unconjugated
100 µl/$450
Select
CBFA2T2 / MTGR1 Rabbit anti-Human Polyclonal (aa1-29) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
Select
CBFA2T2 / MTGR1 Rabbit anti-Human Polyclonal (aa1-29) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
Select
CBFA2T2 / MTGR1 Rabbit anti-Human Polyclonal (aa1-29) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
Select
CBFA2T2 / MTGR1 Rabbit anti-Human Polyclonal (aa1-29) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
Select
CBFA2T2 / MTGR1 Rabbit anti-Human Polyclonal (aa1-29) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
Select
CBFA2T2 / MTGR1 Rabbit anti-Human Polyclonal (aa1-29) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
Select
CBFA2T2 / MTGR1 Mouse anti-Human Polyclonal Antibody
Human
IF, WB
Unconjugated
50 µg/$705
CBFA2T2 / MTGR1 Antibody - Western blot analysis of 293T Raji Jurkat HepG2 cell lysates  using CBFA2T2 Polyclonal Antibody at dilution of 1:1000
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CBFA2T2 / MTGR1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
Select
CBFA2T2 / MTGR1 Rabbit anti-Human Polyclonal (aa554-604) Antibody
Human
IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
Viewing 1-25 of 46 product results



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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).