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CAV1 / Caveolin 1
caveolin 1, caveolae protein, 22kDa
The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.
| Gene Name: | caveolin 1, caveolae protein, 22kDa |
| Synonyms: | CAV1, Caveolin-1, CGL3, CAV, MSTP085, VIP21, BSCL3 |
| Target Sequences: | NM_001753 NP_001744.2 Q03135 |
Publications (9)
1
Epithelial growth factor-induced phosphorylation of caveolin 1 at tyrosine 14 stimulates caveolae formation in epithelial cells. Orlichenko L, Huang B, Krueger E, McNiven MA. The Journal of biological chemistry. 2006 281:4570-9.
[PubMed:16332692]
2
Akt regulates L-type Ca2+ channel activity by modulating Cavalpha1 protein stability. Catalucci D, Zhang DH, DeSantiago J, Aimond F, Barbara G, Chemin J, Bonci D, Picht E, Rusconi F, Dalton ND, Peterson KL, Richard S, Bers DM, Brown JH, Condorelli G. The Journal of cell biology. 2009 184:923-33.
[PubMed:19307602]
[PMC:PMC2699149]
3
Quantitative proteomics of caveolin-1-regulated proteins: characterization of polymerase i and transcript release factor/CAVIN-1 IN endothelial cells. Dvalos A, Fernndez-Hernando C, Sowa G, Derakhshan B, Lin MI, Lee JY, Zhao H, Luo R, Colangelo C, Sessa WC. Molecular & cellular proteomics : MCP. 2010 9:2109-24.
[PubMed:20585024]
[PMC:PMC2953909]
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(1)
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(1)
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(4)
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(106)
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(5)
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(20)
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(3)
Target
CAV1 / Caveolin 1
(149)
Reactivity
Human
(98)
Mouse
(77)
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(55)
Bat
(5)
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(10)
Chicken
(9)
Chimpanzee
(6)
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(14)
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(6)
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(1)
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(7)
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(9)
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(13)
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(3)
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(12)
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(13)
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(23)
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(44)
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(1)
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(1)
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(1)
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(1)
Publications
No
(146)
Yes
(3)
Sample Type
Adherent Cell Cultures
(2)
Ascites
(2)
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(4)
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(4)
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(1)
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(22)
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(1)
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(22)
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(10)
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(1)
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(2)
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(3)
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(3)
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(1)
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(1)
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(1)
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Cancer
CAV1 / Caveolin 1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Rabbit, Mouse, Dog, Guinea pig, Sheep, Bovine, Rat, Pig, Horse, Bat, Human, Monkey
IHC-P
Unconjugated
50 µg/$440
Cancer Pathology
Cancer
CAV1 / Caveolin 1 Goat anti-Human Polyclonal (aa73-84) Antibody
Human, Monkey
IF, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
CAV1 / Caveolin 1 Mouse anti-Human Monoclonal (7C8) Antibody
Mouse, Sheep, Rat, Human
Flo, IF, IHC, IHC-P, IP, WB
Unconjugated
0.1 ml/$460
CAV1 / Caveolin 1 Mouse anti-Human Monoclonal (Biotin) (7C8) Antibody
Mouse, Sheep, Rat, Human
Flo, IF, IHC, IHC-P, IP, WB
Biotin Conjugated
0.1 ml/$416
CAV1 / Caveolin 1 Mouse anti-Human Monoclonal (DY650) (7C8) Antibody
Mouse, Rat, Human
Flo, IF, IHC, IHC-P, IP, WB
DY650 Conjugated
0.1 ml/$416
CAV1 / Caveolin 1 Mouse anti-Human Monoclonal (DY488) (7C8) Antibody
Mouse, Sheep, Rat, Human
Flo, IF, IHC, IHC-P, IP, WB
DY488 Conjugated
0.1 ml/$416
CAV1 / Caveolin 1 Goat anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Dog, Human
IF, IHC-P, WB
Unconjugated
200 µg/$460
Cancer Pathology
Cancer
Fast Shipping
CAV1 / Caveolin 1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human, Monkey
IHC-P
Unconjugated
50 µg/$460
Fast Shipping
CAV1 / Caveolin 1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Dog, Guinea pig, Human, Monkey
IHC-P
Unconjugated
50 µg/$460
CAV1 / Caveolin 1 Mouse anti-Chicken Monoclonal Antibody
Chicken, Human
IF, IHC, IHC-P, IP, WB
Unconjugated
50 µg/$485
Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
Cancer Pathology
CAV1 / Caveolin 1 Rabbit anti-Rat Polyclonal (aa2-105) Antibody
Mouse
ICC, IHC-P, WB
Unconjugated
50 µl/$460
Cancer Pathology
Cancer
CAV1 / Caveolin 1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
ICC, IF, IHC-P, WB
Unconjugated
50 µl/$460
CAV1 / Caveolin 1 Sheep anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
500 µg/$393
Wheat Germ Extract
GST
45.21 kDa
10 µg/$479; 25 µg/$670
Sandwich
96-Well Strip Plate
Human
0.31 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$771
CAV1 / Caveolin 1 Rabbit anti-Human Polyclonal (aa129-178) Antibody
Mouse, Rat, Human
IF, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
Cancer Pathology
Cancer
CAV1 / Caveolin 1 Rabbit anti-Mouse Polyclonal (aa1-104) Antibody
Mouse
IHC-P, WB
Unconjugated
50 µl/$460
CAV1 / Caveolin 1 Rabbit anti-Human Polyclonal (aa2-104) (Biotin) Antibody
Mouse, Human
WB
Biotin Conjugated
100 µl/$308; 200 µl/$350; 500 µl/$489; 1 ml/$558; 2 ml/$749; 5 ml/$1,217
CAV1 / Caveolin 1 Rabbit anti-Human Polyclonal (aa2-104) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
Sandwich
96-Well Microplate
Mouse
39.06 - 2500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
Sandwich
96-Well Strip Plate
Mouse
39.063 - 2500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$768
Sandwich
96-Well Strip Plate
Human
0.234 - 15 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates
1 Plate/$764
CAV1 / Caveolin 1 Rabbit anti-Human Polyclonal (aa164-178) Antibody
Horse, Human, Monkey
ICC, IHC, IHC-Fr, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
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