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CASP8AP2 / FLASH
caspase 8 associated protein 2
A novel mammalian CED-4 homologous was recently identified and cloned in mouse and human and designated FLASH (for FLICE-associated huge protein). FLASH is involved in Fas induced apoptosis. It is recruited to Fas after the receptor cross-linking. Overexpression of wild type of FLASH facilitates and its dominant negative form inhibits Fas induced apoptosis. FLASH interacts with the DEDs of caspase-8 and FADD through the DED-like domain of FLASH and mediates activation of caspase-8 (1). There are parallels between FLASH and Apaf-1/CED-4 although there are arguments against their structural similarity. FLASH is widely expressed.
| Gene Name: | caspase 8 associated protein 2 |
| Family/Subfamily: | Apoptosis |
| Synonyms: | CASP8AP2, CASP8 associated protein 2, CASP8-associated protein 2, CED-4, FLICE associated huge, FLICE-associated huge protein, KIAA1315, FLASH, FLASH homolog RIP25, Human FLASH, RIP25, Caspase 8 associated protein 2 |
| Target Sequences: | NM_012115 NP_036247.1 Q9UKL3 |
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