Human CASP8 / Caspase 8

Rabbit

Human, Rat (tested or 100% immunogen sequence identity)

Mouse (at least 90% immunogen sequence identity)

IgG Polyclonal

Unconjugated

Immunoaffinity purified

Unmodified

Amino acids 240-259 (DKVYQMKSKPRGYCLIINNH-human) were used as the immunogen for this anti-Caspase-8 antibody. This sequence is from the large subunit. Percent identity by BLAST analysis: Human (100%); Mouse (95%); Rat, Ferret, Cat, Elephant, Horse, Dog (85%); Hamster, Rabbit, Guinea pig (80%).

aa240-259

Human CASP8 / Caspase 8

• Western blot (0.5 - 1 µg/ml)

Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases including CASP3/4/6/7/9/10. [UniProt]

Lyophilized from PBS, 2.5% BSA, 0.025% sodium azide/thimerosal.

Reconstitute in sterile distilled water.

Prior to reconstitution, 4°C. Following reconstitution store at -20°C. Avoid freeze-thaw cycles.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: Q14790 NCBI: nm_001228 AAC50645.1