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Anti-CASP4 / Caspase 4 Antibody (N-Terminus) LS-C202788


Wt. Vol. Conc. Price
100 µg - - Unavailable

Most Popular CASP4 / Caspase 4 Antibodies

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Rabbit Polyclonal to Human CASP4 / Caspase 4
IHC - Paraffin, Western blot


Human CASP4 / Caspase 4
Human (tested or 100% immunogen sequence identity)


  • IHC - Paraffin
  • Western blot

Specificity and Use

CASP4 / Caspase 4 antibody was raised against a 16 amino acid peptide from human Caspase-4 amino terminus.
PS 298 recognizes an epitope within the N-terminal region (NT) of Caspase-4, otherwise known as ICH-2. Caspase-4, a member of the Caspase-1 subfamily of cysteine proteases, exists as an inactive pro-enzyme which undergoes proteolytic cleavage of its p30 precursor form, into smaller p20 and p10 subunits. The cellular localization of Caspase-4 on the Endoplasmic Reticulum (ER) membrane, has resulted in this protein becoming a focus of studies in which dysfunction or stress to the ER membrane is implicated, such as Alzheimer's disease and Ischemia (1, 3) and confirms the involvement of Caspase-4 as an instigator of cellular apoptosis. PS 298 detects a band of approximately 34 kD in Ramos cell lysates (predicted precursor MWT 31 kD).


PBS, 0.02% sodium azide
Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
For research use only.

About CASP4 / Caspase 4

P49662 NM_001225 NP_001216.1

CASP4 Antibody, CASP-4 Antibody, Casp11 Antibody, Caspase 4 Antibody, Caspase-4 Antibody, Cysteine protease icerel-ii Antibody, ICE(rel)-II Antibody, ICE(rel)II Antibody, ICH-2 Antibody, Ich-3 Antibody, ICH2 Antibody, Protease ICH-2 Antibody, TX Antibody, Tx protease Antibody, Caspase 11 Antibody, ICEREL-II Antibody, Mih1/TX Antibody, Protease TX Antibody

Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase-1, -4, -5, and -12. Activation of these caspases results in the cleavage and activation of proinflammatory cytokines such as IL-1b and IL-18.

Requested From: 
Date Requested: 4/26/2017

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