Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Bovine (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [107-82]
Specificity and Use
CAPN2 / Calpain 2 / M-Calpain antibody was raised against purified Bovine Skeletal Muscle 80 kD subunit of m-calpain.
This antibody recognizes as epitope between amino acids 502-699 (domain III/IV) of Human calpain Reacts with Human Platelets and Erythrocytes, Bovine platelets, heart and skeletal muscle, Rat myoblasts, kidney, liver and spleen, and pig cultured cells. Does not react with mu-calpain, n-calpain, calmodulin or calpastatin.
PBS-diluted ascites, 0.05% sodium azide
Store at -20°C. Aliquot to avoid freeze/thaw cycles.
The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 2. Multiple heterogeneous transcriptional start sites in the 5' UTR have been reported.