CAMK4 / CaMK IV

calcium/calmodulin-dependent protein kinase IV

Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4+/CD8+ double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18.

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Products

Antibodies (66)

Proteins (10)

ELISA Kits (2)

Type

Cell-Based (1)

Cell-Based Phosphorylation (1)

Over-Expression Lysate (2)

Primary (66)

Recombinant (8)

Target

CAMK4 / CaMK IV (78)

Reactivity

Human (53)

Mouse (41)

Rat (22)

Bat (3)

Bovine (1)

Chicken (2)

Chimpanzee (7)

Dog (6)

Gibbon (3)

Horse (6)

Monkey (4)

Pig (5)

Zebrafish (3)

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Application

IHC (21)

IHC-P (9)

WB (60)

Flo (2)

ELISA (20)

ICC (8)

IF (24)

IP (5)

Peptide-ELISA (4)

RNAi (1)

Host

rabbit (58)

mouse (8)

Product Group

IHCPlus (3)

Isotype

IgG (35)

IgG1 (2)

IgG1,k (1)

IgG2a (1)

Clonality

monoclonal mc (7)

polyclonal pc (59)

Clone

1A3 (1)

8C5B8 (2)

Format

96-Well Microplate (2)

APC Conjugated (2)

Azide-free (1)

Biotin Conjugated (6)

FITC Conjugated (6)

HRP Conjugated (6)

PE Conjugated (2)

Preservative Free (2)

Unconjugated (44)

Epitope

aa405-432 (7)

aa322-371 (4)

aa326-375 (4)

aa363-412 (4)

aa53-102 (4)

140-220 aa (2)

aa425-C-term (2)

pThr196/200 (2)

Amino Acid: 35-292 (1)

Internal (1)

Val192/196 (1)

aa166-215 (1)

aa304-473 (1)

aa350-400 (1)

aa400-425 (1)

p196/200 (1)

pThr196,pThr200 (1)

pThr196/Thr200 (1)

pThr200 (1)

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Publications

No (78)

Sample Type

Adherent Cell Cultures (2)

Tag

GST (1)

GST, N-terminus (2)

His (2)

His-GST (1)

Myc-DDK (Flag) (3)

Species

Human (6)

Mouse (2)

Rat (1)

Source

293T Cells (1)

Baculovirus (2)

E. coli (2)

HEK 293 Cells (2)

Insect Cells (1)

Wheat Germ Extract (2)

Purification

Purified (4)

Low Endotoxin Level

Low endotoxin level (3)

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IHC-plus™ CAMK4 / CaMK IV Antibody (clone 1A3) LS-B6013

(4.0) Rating

Antibody:

CAMK4 / CaMK IV Mouse anti-Human Monoclonal (1A3) Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IHC-P, RNAi, WB

Format:

Unconjugated

Price:

50 µg/$460

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CAMK4 / CaMK IV Antibody (phospho-Thr196/Thr200) LS-C198721

Antibody:

CAMK4 / CaMK IV Rabbit anti-Human Polyclonal (pThr196/Thr200) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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CAMK4 / CaMK IV Antibody (phospho-Thr200) LS-C358930

Antibody:

CAMK4 / CaMK IV Rabbit anti-Human Polyclonal (pThr200) Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

30 µl/$263; 100 µl/$315; 200 µl/$379

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CAMK4 / CaMK IV Antibody (p196/200) LS-C822201

Antibody:

CAMK4 / CaMK IV Rabbit anti-Human Polyclonal (p196/200) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

IHC-plus™ CAMK4 / CaMK IV Antibody LS-B335

(4.0) Rating

Antibody:

CAMK4 / CaMK IV Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Dog, Bovine, Rat, Chimpanzee, Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$515

Select

IHC-plus™ CAMK4 / CaMK IV Antibody (aa166-215) LS-B7641

(4.0) Rating

Antibody:

CAMK4 / CaMK IV Rabbit anti-Human Polyclonal (aa166-215) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$460

Select

CAMK4 / CaMK IV Antibody (Amino Acid: 35-292, clone 8C5B8) LS-C759611

Antibody:

CAMK4 / CaMK IV Mouse anti-Human Monoclonal (Amino Acid: 35-292) (8C5B8) Antibody

Reactivity:

Human

Applications:

Flo, ICC, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$503

Select

CAMK4 / CaMK IV Antibody (clone 8C5B8) LS-C169150

Antibody:

CAMK4 / CaMK IV Mouse anti-Human Monoclonal (8C5B8) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IF, IHC, WB

Format:

Unconjugated

Price:

100 µl/$459

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CAMK4 / CaMK IV Antibody (Internal) LS-C368804

Antibody:

CAMK4 / CaMK IV Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

30 µl/$255; 100 µl/$299; 200 µl/$351

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CAMK4 / CaMK IV Antibody LS-C801656

Antibody:

CAMK4 / CaMK IV Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

CAMK4 / CaMK IV Antibody (phospho-Thr196,pThr200) LS-C801209

Antibody:

CAMK4 / CaMK IV Rabbit anti-Human Polyclonal (pThr196,pThr200) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

CAMK4 / CaMK IV Antibody (phospho-Thr196/200) LS-C822202

Antibody:

CAMK4 / CaMK IV Rabbit anti-Human Polyclonal (pThr196/200) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

CAMK4 / CaMK IV Antibody (phospho-Thr196/200) LS-C416832

Antibody:

CAMK4 / CaMK IV Rabbit anti-Human Polyclonal (pThr196/200) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$305; 100 µg/$357

Select

CAMK4 / CaMK IV Antibody LS-C417653

Antibody:

CAMK4 / CaMK IV Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$305; 100 µg/$357

Select

CAMK4 / CaMK IV Antibody (140-220 aa) LS-C382426

Antibody:

CAMK4 / CaMK IV Rabbit anti-Human Polyclonal (140-220 aa) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

CAMK4 / CaMK IV Antibody (Val192/196) LS-C176393

Antibody:

CAMK4 / CaMK IV Rabbit anti-Human Polyclonal (Val192/196) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

Select

CAMK4 / CaMK IV Antibody LS-C483896

Antibody:

CAMK4 / CaMK IV Rabbit anti-Mouse Polyclonal Antibody

Reactivity:

Mouse

Applications:

ELISA, IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

100 µl/$412

Select

CAMK4 / CaMK IV Antibody LS-C483900

Antibody:

CAMK4 / CaMK IV Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ICC, IF, WB

Format:

Unconjugated

Price:

100 µl/$412

Select

CAMK4 / CaMK IV Antibody LS-C333999

Antibody:

CAMK4 / CaMK IV Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

Select

CAMK4 / CaMK IV Antibody (140-220 aa) LS-C380640

Antibody:

CAMK4 / CaMK IV Rabbit anti-Human Polyclonal (140-220 aa) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

CAMK4 / CaMK IV Antibody (Preservative Free) LS-C815538

Antibody:

CAMK4 / CaMK IV Rabbit anti-Human Polyclonal (Preservative Free) Antibody

Reactivity:

Human

Applications:

ICC, IF, IHC-P

Format:

Unconjugated, Preservative Free

Price:

100 µl/$412

Select

CAMK4 / CaMK IV Antibody (aa425-C-term) LS-C287379

Antibody:

CAMK4 / CaMK IV Rabbit anti-Human Polyclonal (aa425-C-term) Antibody

Reactivity:

Human

Applications:

IHC, IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

CAMK4 / CaMK IV Antibody LS-C483898

Antibody:

CAMK4 / CaMK IV Rabbit anti-Mouse Polyclonal Antibody

Reactivity:

Mouse

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

100 µl/$412

Select

CAMK4 / CaMK IV Antibody (aa405-432) LS-C319993

Antibody:

CAMK4 / CaMK IV Rabbit anti-Mouse Polyclonal (aa405-432) Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

CAMK4 / CaMK IV Antibody (aa304-473) LS-C377398

Antibody:

CAMK4 / CaMK IV Rabbit anti-Human Polyclonal (aa304-473) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µl/$294; 100 µl/$360

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